Synthetic Route of 3068-00-6 , The common heterocyclic compound, 3068-00-6, name is 1,2,4-Butanetriol, molecular formula is C4H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A 100 mL RBF was charged with dilinolenyl ketone (Compound 55) (4.2 g, 8.2 mmol), 1,2,4-butanetriol (3.4 g, 32 mmol), PPTS (200 mg, 0.8 mmol) and a stir bar. The flask was flushed with nitrogen and anhydrous toluene (60 mL) added. The reaction vessel was fitted with a Dean Stark tube and condenser and brought to reflux and the reaction was left overnight. After cooling to room temperature, the reaction mixture diluted with toluene (50 mL), and washed with 5% aq. Na2CO3 (2 x 50 mL), water (50 mL), dried (MgSO4) and purified by chromatography to yield 3.0 g (4.9 mmol, 59%) of the ketal.
The synthetic route of 3068-00-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PROTIVA BIOTHERAPEUTICS, INC.; HEYES, James; PALMER, Lorne; MASLOWSKI, Magdalena; MACLACHLAN, Ian; WO2011/106; (2011); A1;,
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