Reference of 18776-12-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 18776-12-0 as follows.
In 250ml three-necked flask was added 3-chlorophenyl propanol 10g,9.29 g of 1-naphthol and 100 ml of DMF,Stirring to dissolve, solution temperature control at about 5 , adding sodium hydroxide 2.34g,The reaction at 0 ~ 5 for 30 minutes, and then slowly warmed to 50 ~ 55 for 8 hours to obtain a reaction solution,The reaction solution was cooled to about 0 C, ice water 100ml, extracted with toluene 60ml * 3, andAnd the organic layer, respectively, the organic layer was washed with water 100ml,1% sodium hydroxide 100ml * 4 washing, 100ml * 4 washed with water and saturated brine 100ml, and then dried, suction filtered, concentrated under reduced pressure at 50 C,To obtain a concentrate, take concentrate 34.6g, 207ml of n-hexane and 17.8ml of ethyl acetate was added to a three-necked flask,The mixture was heated to 25-35 C for 2 hours, then cooled to 0-5 C, stirred for 3 hours and filtered. The cake was washed with a small amount of n-hexane and ethyl acetate and dried at 40 C.19.3 g of 1-phenyl-3- (1-naphthalenyloxy) -1-propanol was obtained.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,18776-12-0, its application will become more common.
Reference:
Patent; Anhui Jinnan Medical Treatment Technology Co., Ltd.; Hu Huiping; Li Jie; Lu Hai; Tang Zhongyao; (10 pag.)CN106748817; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts