Month: July 2021

Adding a certain compound to certain chemical reactions, such as: 1004-24-6, (4-Methylenecyclohexyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1004-24-6, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C8H14O

PREPARATION 8 4-Methylenecyclohexane-1-carbaldehyde To pydridinium dichromate (223 g., 0.59 mole) in 1 liter CH2 Cl2, stirring under N2, was added dropwise 4-methylene-1-cyclohexanemethanol (50 g., 0.40 mole) in 75 ml. CH2 Cl2 over a few minutes. After stirring for 21 hours at room temperature, the reaction mixture was heated at 60 C. for 24 hours. The reaction mixture was cooled, diluted with 400 ml. ether and decanted from solids. The solids were slurried with 400 ml. of fresh ether and decanted. The combined organic decants were filtered over fluorasil and diatomaceous earth and the filtrate concentrated in vacuo to an oil (41 g.) and distilled to yield title product, 13.6 g., b.p. 82-90/15-20 mm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1004-24-6, its application will become more common.

Reference:
Patent; Pfizer Inc.; US4430337; (1984); A;,
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Adding a certain compound to certain chemical reactions, such as: 13826-35-2, (3-Phenoxyphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: (3-Phenoxyphenyl)methanol, blongs to alcohols-buliding-blocks compound. name: (3-Phenoxyphenyl)methanol

In 1000ml four-necked flask (equipped with lye absorption device) was added 500g of dichloromethane, stirring was started to continue the addition of 100g m-phenoxybenzyl alcohol and 30g of tetramethylethylenediamine.Cooling to -35 C, began to drop prepared 70g of thionyl chloride and methylene chloride solution. During the dropwise addition temperature was controlled at -45 C. After the addition was completed at -45 heat 4h. After that, the reaction solution was pouredInto 1000ml of water, stirring, phase separation, the organic phase were washed with 600ml of water, phase separation. The organic phase was desolvated to 100 C under atmospheric pressure and the solvent methylene chloride was recovered. Then decompression (vacuum degree 0.097MP) fractionation, intermediates chloroacenesulfonic acid phenoxybenzyl 127g. Purity 99%, yield 90%.

The synthetic route of 13826-35-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Tianjin Jinlvbao Pesticide To Make Co., Ltd.; Wang Baojun; Cui Weizhong; Lu Sen; (8 pag.)CN106495994; (2017); A;,
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Related Products of 100442-33-9, Adding some certain compound to certain chemical reactions, such as: 100442-33-9, name is 1-(3,3-Diphenyl-N-methylpropylamino)-2-methyl-2-propanol,molecular formula is C20H27NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 100442-33-9.

Step-ll; 2,N-Dimethyl-N-(3,3-diphenylpropyI)-1-amino-2-propanol (5.0 gm) is dissolved in methylene chloride (25 ml) at 25 – 300C, triethylamine (2.5 gm) is added and then the contents are cooled to 10 – 150C under N2 atmosphere. Trimethylsilyl chloride (2.5 gm) is slowly added to the reaction mass while maintaining the temperature in between 10 – 150C, the mass temperature is raised to 25 – 300C and maintain for 2 hours at the same temperature to give the reaction mass having 2,N-dimethyl-2-(trimethylsilyIoxy)-N-(3,3-diphenylpropyl)- 1-propanamine.

According to the analysis of related databases, 100442-33-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; HETERO DRUGS LIMITED; WO2006/134606; (2006); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 627-18-9, name is 3-Bromopropan-1-ol, the common compound, a new synthetic route is introduced below. Formula: C3H7BrO

To a stirring solution of concentrated sulfuric acid (30 mmol) was slowly added concentrated nitric acid (30 mmol) dropwise at 0 C under nitrogen, and stirred for 10 min followed by the addition of 3-bromopropanol 3 (3.5 g, 25 mmol) in anhydrous dichloromethane (5 mL) dropwise while keeping the temperature below 5 C. After 3 h, the reaction was quenched with water (10 mL), followed by addition of dichloromethane (40 mL). The organic phase was separated, washed with water (15 mL), dried (MgSC ) and concentrated to give bromopropyl nitrate 4, which was used in the next step without further purification.

The synthetic route of 627-18-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; VIRGINIA COMMONWEALTH UNIVERSITY; SAFO, Martin, K.; DANSO-DANQUAH, Richmond; GHATGE, Mohini; VENITZ, Jurgen; MANGINO, Martin; WARD, Kevin, R.; WO2015/100235; (2015); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 945-24-4, name is (2,4-Diaminopteridin-6-yl)methanol. A new synthetic method of this compound is introduced below., Formula: C7H8N6O

To a solution of triphenylphosphene (408 mg, 1 .03 mmol) in anhydrous DMA ( 1 mL) is added bromine dropwise at 0 0C (0.08 mL, 1 .03 mmol) under N2 atmosphere. After stirring for 5 additional minutes, (2,4-diaminopteridin-6-yl)methanol (100 mg, 0.33 mmol) is added at once and the reaction mixture is stirred at RT for 18 h. Barium oxide ( 100 mg, 0.65 mmol) is then added to the reaction mixture followed by 3-aminobenzoic acid (107 mg, 0.78 mmol) at RT. The reaction mixture is then heated at 56 0C and stirred at that temperature for 24 h and cooled to RT. The mixture is diluted with methylene chloride (5 mL) and the resulting brownish precipitate is filtered. The solids are washed with water and methanol. The solids are then taken in methanol and heated at reflux for 2 h. After cooling to RT, the solids are filtered again and dried overnight in a heated vacuum oven to give 45 mg product (Yield: 26.9%) as a brownish yellow solid. 1 H NMR (500 MHz, DMSOd6) delta 4.6 (br s, 2H), 6.7 (s, 1 H), 6.9-7.0 (d, 1 H), 7.15-7.3 (m, 2H), 7.38 (br s, 2H), 8.6-8.7 (br s, I H), 8.9 (s, I H), 9.3-9.4 (m, 2H), 12.8 (br s, I H); LC-MS m/z 312 (MH+), retention time 1 1 .48 min., HPLC Method B.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 945-24-4, (2,4-Diaminopteridin-6-yl)methanol.

Reference:
Patent; BIORELIX, INC.; COISH, Philip, D., G.; WICKENS, Phil; DIXON, Brian; OSTERMAN, David; KHIRE, Uday, R.; NAVIA, Manuel; BERMAN, Judd; KAUR, Harpreet; WILSON, Jeffrey; UNDERWOOD, Dennis; WO2010/110907; (2010); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 17100-58-2, name is (4-Bromo-2-methylphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

Step B: 4-Bromo-1-chloromethyl-2-methyl-benzene(4-Bromo-2-methyl-phenyl)-methanol (40.0 g, 199 mmol) was added to thionyl chloride (106.6 g, 0.896 mole, 65.3 mL) .The mixture was heated to reflux, for 1.5 hours. After cooling to room temperature the mixture was concentrated under reduced pressure. The residue was dissolved in EtOAc (300 mL) and added carefully to saturated aqueous NaHC03 (500 mL). The EtOAc layer was separated, and the aqueous layer was extracted with EtOAc (250 mL). The combined organic layers were dried (Na2S04), filtered and concentrated in vacuo yielding the title compound (34.19 g, 157 mmol, 79 %) as a slightly colored oil that solidified to a white solid upon standing.1 H NMR (CDCI3, 300 MHz) delta ppm 2.38 (s, 3H); 4.57 (s, 2H); 7.12 (d, 1 H); 7.28 (s, 1 H); 7.55 (d, 1 H)

With the rapid development of chemical substances, we look forward to future research findings about 17100-58-2.

Reference:
Patent; PFIZER INC.; BROWN, Matthew Frank; MARFAT, Anthony; MELNICK, Michael Joseph; REILLY, Usa; WO2011/45703; (2011); A2;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39895-56-2, name is (4-(Aminomethyl)phenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of (4-(Aminomethyl)phenyl)methanol

To a solution of (2R,5S,8R, 14S,17R,20S,21S,22S,E)-8-benzyl-20-((E)-but-2-en- 2-yl)-14-((R)-sec-butyl)-2-isobutyl-557510, 17,2 l,25-hexamethyl-3,6,9, 12,15, 18,26-heptaoxo- 1 , 19-dioxa-4,7, 10, 13, 16-pentaazacyclohexacos-24-en-22-yl (4-nitrophenyi) carbonate (5.0 mg, 5.044 muetaiotaomicron, 1.0 eq; Intermediate 1 from Example 1) in DCM (0.1 mL, 5.04 muetaiotaomicron) was added (4-(aminomethyl)phenyl)methanol (3.46 mg, 0.025 mrnol , 5.0 eq) and DIPEA (8.81 muEpsilon, 0.050 mrnol, 10.0 eq) and stirred overnight. The reaction was monitored by reverse phase HPLC. The reaction mixture was concentrated on the rotavap and the crude residue obtained was purified by reverse phase flash chromatography (acetonitrile with 0.1% formic acid/ H20 with 0.1 % formic acid) to afford (2R,5S,8R,14S,17R,20S,21S,22S,E)-8-benzyl-20-((E)-but- 2-en-2-yl)-14-((R)-sec-butyl)-2-isobutyl-557 0,17,21,25-hexamethyl-356,9, 12s 15,18526- heptaoxo- 1 , 19-dioxa~4,7, 10, 13,16-pentaazacyclohexacos~24-en~22-yl ( – (hydroxymethy])benzyl)carbamate (2.75 mg, 2.78 muetaiotaomicron, 55.1 %). Observed HRMS (ESI) m/z: 989.565 | M 1 11

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 39895-56-2, (4-(Aminomethyl)phenyl)methanol.

Reference:
Patent; SIRENAS LLC; USUI, Ippei; LEE, Bryan, Junn; COHEN, Steven, Bruce; MACHERLA, Venkat, Rami Reddy; BEVERAGE, Jacob, Neal; PAN, Chung-mao; BARMARE, Farhana; ESQUENAZI, Eduardo; (265 pag.)WO2018/45245; (2018); A1;,
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Related Products of 722-92-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, molecular formula is C9H7F6NO, molecular weight is 259.15, as common compound, the synthetic route is as follows.

Dichloroglyoxime (0.160 g, 1 mmol) was dissolved in 15 mL of absolute ethanol and was added dropwise to a solution of 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol (1.04 g, 4 mmol) in 10 mL of absolute ethanol.The mixture was stirred overnight. Water was added dropwise until a white precipitate formed. It was filtered off, washed with water, and then dried. Compound 2 is soluble in acetone, DMSO, DMF, and THF. Yield:56%; mp 67 C; found: C 39.80, H 2.30, N 9.25; calc. for C20 H14 F12 N4 O4 : C 39.88, H 2.34, N 9.30, IR, numax(cm-1) : 3400 (NH), 3200 (OH), 1610 (C=N), 1519, 1372, 1267 (C-F), 1186 (C-F), 1108, 963 (N-O), 931, 825, 705. 1 H NMR (DMSO-d6) , (ppm): 11.00 (s, 2H, NOH, disappeared upon D2 O), 9.00 (b, 2H, ArCH-OH),8.77-8.51 (d, 4H, Ar-H), 7.66-7.29 (d, 4H, Ar-H), 6.71 (s, 2H, NH); MS (ES), (m/z): 602.3 [M]+.

Statistics shows that 722-92-9 is playing an increasingly important role. we look forward to future research findings about 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol.

Reference:
Article; Harbeck, Mika; ?en, Zafer; Erbahar, Dilek; Guemue?, Guelay; Musluo?lu, Emel; Turkish Journal of Chemistry; vol. 43; 3; (2019); p. 890 – 901;,
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Synthetic Route of 583-03-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 583-03-9, name is 1-Phenylpentan-1-ol, molecular formula is C11H16O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The typical reaction steps are as follows:1 mmol of the starting alcohol of the reactant column shown in Table 2,OH – Ni3In-LDH 14 mg,Mesitylene 5mL were added to the reactor,Into the oxygen,Atmospheric reaction,The reaction was stirred at 60 for a certain period of time.The solid catalyst was removed by filtration,Using gas chromatography internal standard method (chlorobenzene as internal standard) to analyze the content of liquid products,Calculate yield.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 583-03-9, 1-Phenylpentan-1-ol.

Reference:
Patent; Changzhou University; Zhou Weiyou; Dai Xuan; He Mingyang; Sun Fuan; Pan Jiugao; (8 pag.)CN107176898; (2017); A;,
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Electric Literature of 149965-40-2, Adding some certain compound to certain chemical reactions, such as: 149965-40-2, name is (5-Bromo-2-chlorophenyl)methanol,molecular formula is C7H6BrClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 149965-40-2.

A mixture of 5-bromo-2-chlorobenzyl alcohol (2.22 g), tert-butyldimethylsilyl chloride(2.26 g), imidazole (1.36 g) and DMF (25 ml) was stirred at ambient temperature for 1 hour.The mixture was evaporated and the residue was partitioned between ethyl acetate and water.The organic phase was washed in turn with water and with a saturated brine solution, driedover anhydrous sodium sulphate and evaporated. The residue was purified by columnchromatography on silica using an increasingly polar gradient of from 0% to 40% ethyl acetatein isohexane as eluent. There was thus obtained 3-ter^butyldimethylsilyloxymethyl-4-chlorobromobenzene as an oil (2.78 g) which was used without further purification.

According to the analysis of related databases, 149965-40-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/5914; (2006); A1;,
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