Month: July 2021

Related Products of 623-04-1 , The common heterocyclic compound, 623-04-1, name is (4-Aminophenyl)methanol, molecular formula is C7H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 4-aminobenzyl alcohol (2.0g, 16.24mmol) in dry DMF (20mL) were added tert-butyldimethylsilyl chloride (3.67g, 24.35mmol) and imidazole (2.21g, 32.46mmol), the resulting mixture was further stirred for 5hat room temperature. The reaction mixture was then diluted with saturated brine solution and extracted with CH2Cl2. The organic layer was separated and washed with brine solution for several times, then dried over anhydrous Na2SO4, evaporated under vacuum, the obtained brown residue was purified by silica gel chromatography (petroleum ether-ethyl acetate), a brown oil was obtained (3.15g, 82%). 1H NMR (CDCl3, 400MHz) delta7.12 (d, 2H, J=8.4Hz), 6.67 (d, 2H, J=8.0Hz), 4.62 (s, 2H), 3.80 (brs, 2H), 0.91 (s, 9H), 0.08 (s, 6H).

The synthetic route of 623-04-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Fei, Qiang; Zhou, Li; Wang, Feiyi; Shi, Ben; Li, Chunbao; Wang, Rui; Zhao, Chunchang; Dyes and Pigments; vol. 136; (2017); p. 846 – 851;,
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Adding a certain compound to certain chemical reactions, such as: 106-28-5, (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol, blongs to alcohols-buliding-blocks compound. name: (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol

Example 11. Synthesis of Acetic acid 3,7,11-trimethyl-dodeca-2,6,10-trienyl ester, or Farnesyl acetate To a solution of farnesol (100g, 0.45 mol), potassium carbonate (90 g, 0.65 mol) and 4-dimethylamino pyridine (0.5 g) in EtOAc (300 ml) at 0C, acetic anhydride (66.5 g, 0.65 mol) was added dropwise. The reaction was finished in 2 hrs. All the contents of the reaction flask were transferred to a conical flask containing EtOAc (600 ml) and treated with the dropwise addition of a saturated NaHCO3 solution. After neutralization, the organic layer was separated and washed with water (2 x 80 ml), brine (80 ml), and dried over MgSO4 and then removed under vacuum to yield the farnesyl acetate (108 g, 92%). 1H NMR(400 MHz, CDCl3): 5.34 (t, 1H, J = 6.04 Hz), 5.07 (m, 2H), 4.57 (d, 2H, J = 6.84 Hz), 2.10-2.05 (m, 11H), 1.97-1.95 (m, 2H), 1.68-1.66 (m, 6H), 1.58 (s, 6H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,106-28-5, (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Mehta, Dilip; Eburon Organic International; Mohan, Priya; Shastri, Mayank; Reid, Ted; EP2868658; (2015); A1;,
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Synthetic Route of 33420-52-9, Adding some certain compound to certain chemical reactions, such as: 33420-52-9, name is 2,2-Difluoropropan-1-ol,molecular formula is C3H6F2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33420-52-9.

To a cooled (0 C) solution of 2,2-difluoropropan-l-ol (3.17 g, 33.0 mmol) and pyridine (2.97 mL, 36.7 mmol) in CH3CN (100 mL) was added dropwise Tf20 (5.70 mL, 33.8 mmol). The reaction was stirred for 30 min at 0 C. To the cooled slurry was added a cold solution of methyl 4-methyl-5-(l-(piperidin-4-yl)propyl)thiophene-3 -carboxylate hydrochloride (2.6 g, 7.34 mmol) and K2C03 (9.13 g, 66.0 mmol) in CH3CN (20 mL). The reaction was allowed to warm to RT, then heated at 50 C overnight. The reaction was evaporated to dryness under vacuum, taken up in DCM, washed with water, brine, dried (Na2S04), filtered, and concentrated under vacuum. The residue was purified by silica gel chromatography (Isco RediSep Rf Gold 120 g, 5% EtOAc:hexanes) to give methyl 5-(1- (1-(2,2-difluoropropyl)piperidin-4-yl)propyl)-4-methylthiophene-3-carboxylate (2.05 g, 5.42 mmol, 73.8 % yield) as a yellow oil. 1H NMR (400 MHz, CDCl3) delta 8.00 (s, 1H), 3.85 (s, 3H), 2.99 (d, J=11.12 Hz, 1H), 2.86 (d, J=11.12 Hz, 1H), 2.53-2.75 (m, 3H), 2.37 (s, 3H), 2.04-2.27 (m, 2H), 1.84-2.01 (m, 2H), 1.62 (t, J=18.69 Hz, 4H), 1.30-1.47 (m, 5H), 0.76 (t, J=7.33 Hz, 3H). MS(ES) [M+H]+ 360.2.

According to the analysis of related databases, 33420-52-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; KNIGHT, Steven David; NEWLANDER, Kenneth Allen; TIAN, Xinrong; (112 pag.)WO2016/66697; (2016); A1;,
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Synthetic Route of 27489-62-9 ,Some common heterocyclic compound, 27489-62-9, molecular formula is C6H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

4.2.31 8-(trans-4-Hydroxycyclohexylamino)-1-(3-morpholinopropyl)oxazolo[4,5-g]quinazolin-2(1H)-one (6e) Trans-4-aminocyclohexanol (148 mg, 1.28 mmol) and TEA (150 mg, 2.14 mmol) was added to a solution of compound 13 (300 mg, 1.07 mmol) in isopropanol (12 ml) and stirred at 60 C for 24 h. The mixture was cooled to room temperature and concentrated in vacuo, the residue was treated with aqueous NaHCO3 (10 ml) and extracted with EtOAc/MeOH (20:1, 30 ml). The organic layer was washed with brine, dried over MgSO4, and concentrated. Chromatography of the residue on silica gel with DCM-MeOH (90/1,v/v) gave 361 mg (yield, 79%) of the title compound as pale yellow solid: Mp: 312-315 C; HRMS, ESI+, m/z: Calcd for C22H30N5O4 (M + H)+, 428.2292; found, 428.2295; 1H NMR (500 MHz, DMSO-d6) delta:8.70 (1H, s), 7.80 (1H, s), 7.74 (1H, s), 4.14 (1H, s), 4.00 (2H, t, J = 6.4 Hz), 3.52 (4H, t, J = 4.2 Hz), 2.33 (2H, t, J = 6.3 Hz), 2.26 (4H, m), 2.00 (2H, p, J = 6.4 Hz); 13C NMR (75 MHz, DMSO-d6) delta:165.61, 159.43, 153.45, 153.26, 152.57, 152.00, 148.36, 148.27, 147.64, 147.03, 134.26, 132.23, 120.73, 112.49, 106.61, 106.06, 106.38, 101.58, 100.19, 66.00, 65.86, 55.01, 54.77, 54.15, 53.16, 53.12, 40.59, 40.33, 22.19, 22.91.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 27489-62-9, trans-4-Aminocyclohexanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Lin, Jinsheng; Shen, Wei; Xue, Jingwei; Sun, Juan; Zhang, Xue; Zhang, Can; European Journal of Medicinal Chemistry; vol. 55; (2012); p. 39 – 48,10;,
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Related Products of 4728-12-5 ,Some common heterocyclic compound, 4728-12-5, molecular formula is C7H14O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To dichloromethane solution (100 ml) of 14 (6.38 g, 43.64 mmol), triethylamine (9.08 ml, 65.47 mmol) was added, and methane sulfonyl chloride (3.69 ml, 48.01 mmol) was dropped while cooling in ice with shaking, and stirred for 30 min at the same temperature. The reaction mixture was added cold water, and extracted with ethyl acetate. The extract was washed with water, dried, and evaporated to dryness under reduced pressure, and the residue was purified by silica gel column chromatography (solvent: ethyl acetate/n-hexane = 1/2), to obtain 15 (9.66 g, 99percent) of oily light yellow substance. APCI-MS m/z 225[M+H]+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4728-12-5, its application will become more common.

Reference:
Patent; Tohoku University; EP2103611; (2009); A1;,
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Related Products of 96-35-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 96-35-5, name is Methyl 2-hydroxyacetate. This compound has unique chemical properties. The synthetic route is as follows.

A mixture ofmethyl 2-hydroxyacetate (9 g, 0.1 mol,equiv) and hydrazine hydrate (9.6 ml, 1.5 equiv, 85%) in methanol (100 ml) was refluxed for 8 h before methanol and exceesive hydrazine hydrate were evaporated. Toluene was added and evaporated again to remove the residual water to give the title compound as a white solid which could be used in next step without further purification.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 96-35-5, Methyl 2-hydroxyacetate.

Reference:
Patent; Shen, Jianhua; Wang, Yiping; Wang, Kai; US2014/171431; (2014); A1;,
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Synthetic Route of 2568-33-4, Adding some certain compound to certain chemical reactions, such as: 2568-33-4, name is 3-Methylbutane-1,3-diol,molecular formula is C5H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2568-33-4.

Step 1: 4-Chloro-2-methyl-butan-2-ol 10.0 g (96.0 mmol)_3-methyl-1 ,3-butandiol is dissolved in 30.0 ml toluene and 10.7 g (106 mmol) TEA is added. The funnel is rinsed with 10.0 ml toluene. The mixture is heated to 80C and a mixture of 1 1 .6 g (101 mmol) methanesulfonyl chloride and 3.00 ml toluene is added. After complete addition, the funnel is rinsed with 7.00 ml toluene and the reaction mixture is heated to reflux for approx. 3h. After full conversion (GC) the mixture is cooled to 20 C and 40.0 ml water is added. Stirring is continued for a short period and the aqueous phase is separated. Then, approx. 10 ml of the organic phase is distilled off in vacuum. The crude toluene solution of the product is used for the next step.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2568-33-4, 3-Methylbutane-1,3-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; DAHMANN, Georg; WAGNER, Holger; ECKHARDT, Matthias; FRANK, Markus; SANTAGOSTINO, Marco; SCHNAUBELT, Juergen; STERTZ, Uwe; PACHUR, Thorsten; WO2015/44073; (2015); A1;,
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Related Products of 110-73-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 110-73-6, name is 2-(Ethylamino)ethanol. A new synthetic method of this compound is introduced below.

In a 100 mL 1-neck round bottom flask [A-1] (Benzenesulfonate Dichlorosulfofluorescein) (3g, 7.40mmol, 1eq), [A-2] (2-(Ethylamino)ethanol) (5.28g, 59.22mmol, 8eq), After adding 50 g of di-water, the mixture was stirred at 100C. Thereafter, the reaction was performed overnight (overnight, 12 hours). The reaction was terminated by quenching in 1M HCl solution, NaCl (sodium chloride) was added to precipitate the reaction. The resulting precipitate was filtered under reduced pressure and dried in an oven at 80C. DMF (Dimethylformamide) to remove NaCl between products after drying After dissolving in filtration, the filtrate was diethyl ether Quenching on The mixture was filtered under reduced pressure and dried to obtain Compound A (2.88 g, 5.64 mmol, 76%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,110-73-6, 2-(Ethylamino)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; LG Chem, Ltd.; Choi Sang-a; Lee Da-mi; Yang Seung-jin; Lee Jae-yong; Kim Hye-jin; Kim Yeong-ung; (47 pag.)KR2020/46212; (2020); A;,
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Electric Literature of 5299-60-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5299-60-5, name is Ethyl 6-hydroxyhexanoate. A new synthetic method of this compound is introduced below.

General procedure: According to a modified literature procedure,[2] a flame-dried Schlenk flask is charged withpoly(4-vinylpyridine) (2.1 equiv) in CH2Cl2. At 0 C, Tf2O (1.1 equiv) is added dropwisefollowed by the addition of the corresponding primary alcohol in CH2Cl2. The reaction mixtureis then allowed to warm to room temperature. After completion of reaction (TLC monitoring),the reaction mixture is filtered under gravity, and the residue is washed with CH2Cl2.Evaporation of the solvents at room temperature (due to decomposition of the triflates athigher temperatures) affords the crude title compounds. Purification by vacuum filtration oversilica gel using a sintered funnel (grade 4) with the indicated eluent affords the analyticallypure alkyltriflates.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5299-60-5, its application will become more common.

Reference:
Article; Scharfbier, Jonas; Oestreich, Martin; Synlett; vol. 27; 8; (2016); p. 1274 – 1276;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16369-21-4, name is 2-(Propylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 16369-21-4

General procedure: [HEA][HCO2], [HEPA][HCO2], [BHEA][HCO2], and [DEHEA][HCO2] were prepared by dropping the stoichiometric amount of formic acid to corresponding amino alcohol at 0 C. The reaction mixture was stirred at rt for 2 h under argon atmosphere. After completion of the reaction, the ionic liquid was washed with EtOAc and Et2O. The ionic liquid was dried in vacuo at 40 C.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 16369-21-4, 2-(Propylamino)ethanol.

Reference:
Article; Suzuki, Hideyuki; Yoshioka, Seiki; Igesaka, Ami; Nishioka, Hiromi; Takeuchi, Yasuo; Tetrahedron; vol. 69; 31; (2013); p. 6399 – 6403;,
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