Month: July 2021

Reference of 124-68-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 124-68-5, name is 2-Amino-2-methyl-1-propanol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2-Amino-2-methyl-1-propanol (9.5 mL, 0.1 mol) and triethylamine (14 mL, 0.1 mol) were dissolved in 200 mL chloroform. The solution was cooled to 0 C using an ice bath, and added a solution of acryloyl chloride (8.0 mL, 0.1 mol) in 50 mL chloroform. The reaction mixture was then stirred for 4 h while keeping the temperature at 0 C. Triethylamine hydrochloride was precipitated from the solution, and removed by filtration. The filtrate was concentrated and purified by column chromatography using ethyl acetate/hexane (7/3, v/v) as the eluent. The HTBAM monomer was obtained as a white powder and the yield was 66.0%. 1H NMR (CDCl3, delta, ppm): 1.34 (s, 6H, C(CH3)2CH2OH), 3.62 (d, 2H, C(CH3)2CH2OH), 5.67, 6.10 (dd, dd, 2H, CH2=CH), 6.27 (dd, 1H, CH2=CH). 13C NMR (CDCl3, delta, ppm): 24.11 (C(CH3)2CH2OH), 55.84 (C(CH3)2CH2OH), 70.19 (C(CH3)2CH2OH), 126.48 (CH2=CH), 130.65 (CH2=CH), 165.93 (C=O). HR-MS (ESI): calcd for C7H13NO2 [M+H]+: 144.10191, found: 144.10186.

According to the analysis of related databases, 124-68-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Cui, Qianling; Wang, Yajie; Wu, Feipeng; Wang, Erjian; Polymer; vol. 54; 17; (2013); p. 4521 – 4527;,
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Synthetic Route of 101597-25-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 101597-25-5 as follows.

Preparation of 2-(2-(2-(2-(4-(hydroxybis(4-methoxyphenyl)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethanol (5d) The following are added to 100 mL of DCM/H2O mixture (1/1): 3 (1.988 g; 9.07 mmol; 1 eq.), 4d prepared according to Gabbutt, C. D.; Heron, B. M.; Instone, A. C.; Thomas, D. A. Partington, S. M.; Hursthouse, M. B.; Gelbrich, T. Eur. J. Org. Chem. 2003, 7, 1220; (2.379 g; 9.07 mmol; 1 eq.) and CuBr (0.260 g; 1.814 mmol; 0.2 eq.). The solution is stirred vigorously for 20 h and extracted with DCM and washed with a saturated solution of NH4Cl. The organic phase is dried (MgSO4), filtered and concentrated under vacuum. The crude product is purified (flash chromatography, silica gel, eluent DCM/MeOH) to give 5d in the form of an oil (3.463 g; 7.19 mmol; 79%). Rf (SiO2, DCM/MeOH (95/5)): 0.15,

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,101597-25-5, its application will become more common.

Reference:
Patent; INSERM (Institut National de la Sante et de la Recherche Medicale); Bertrand, Philippe; Delatouche, Regis; Heroguez, Valerie; Collette, Floraine; Gregoire, Marc; Blanquart, Christophe; Gueugnon, Fabien; US2014/219925; (2014); A1;,
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Electric Literature of 64372-62-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 64372-62-9, name is 2-Chloro-5-(trifluoromethyl)benzyl alcohol, molecular formula is C8H6ClF3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 14a (3.30 g), (2-chloro-5-(trifluoromethyl)phenyl)methanol (15a) (2.94 g), K2CO3 (5.5 g), water (5 mL) and THF (14 mL) was degassed with N2 for 90 min. Bis(di-t-butylphosphino)ferrocene palladium(II) dichloride (170 mg) was added and the mixture heated at 37-40 C. for 24 hr with vigorous stirring. The reaction mixture was cooled to room temperature, diluted with water (20 mL) and extracted with MTBE (50 mL*3). The combined organic solution was washed with brine, dried (Na2SO4), filtered and the solvent removed under reduced pressure. The crude product was purified by chromatography on silica gel to give 4.6 g (88%) of 16a containing a small amount of the corresponding benzaldehyde (via oxidation of the alcohol during reaction). 1H NMR (CDCl3) delta 7.95, (s, 1H), 7.6 (d, 1H), 7.28 (d, 1H), 6.98 (d, 1H), 6.69 (d, 1H), 4.59 to 4.38 (m, 2H), 3.75 (s, 3H), 1.99 (t, 1H); MS m/z=332 (M+H-H2O).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 64372-62-9, 2-Chloro-5-(trifluoromethyl)benzyl alcohol.

Reference:
Patent; CONCERT PHARMCEUTICALS, INC.; US2008/242711; (2008); A1;,
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Electric Literature of 109240-30-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 109240-30-4, name is 1-(4-Bromophenyl)cyclopropanol. A new synthetic method of this compound is introduced below.

General procedure: An argon-degassed solution of cyclopropanol 1 (1 equiv) in t-BuOH (0.02 M) was added dropwise over 2 h to an argondegassed,stirred solution of 2-isocyano biphenyl 2 (2 equiv)and manganese(III) acetylacetonate (2.2 equiv) in t-BuOH(0.042 M) at 26 C. The resulting solution (0.01 M with respectto the cyclopropanol) was stirred for an additional 5 min beforethe solvent was removed under reduced pressure, and theresulting residue purified by flash chromatography to yield thedesired 2-substituted phenanthradine 3.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,109240-30-4, 1-(4-Bromophenyl)cyclopropanol, and friends who are interested can also refer to it.

Reference:
Article; Davis, Dexter C.; Haskins, Christopher W.; Dai, Mingji; Synlett; vol. 28; 8; (2017); p. 913 – 918;,
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Application of 27489-62-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 27489-62-9, name is trans-4-Aminocyclohexanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a flask was added 29 B008 (0.4g, 1.07mmol), 102 DMSO (10mL), 103 K2CO3 (0.3g, 2.14mmol), 104 3-chloro-4-fluoroaniline (0.31g, 2.14mmol). The mixture was heated and stirred at 90C for 8h, cooled to rt, poured into ice-water (50mL). The solid was collected by filtration and recrystallized from methanol 4 times to afford a white 105 solid (0.23g, yield 45%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 27489-62-9, trans-4-Aminocyclohexanol.

Reference:
Article; Feng, Yue; Xie, Xiao-Yang; Yang, Yi-Qiu; Sun, Yu-Tong; Ma, Wen-Hui; Zhou, Peng-Jun; Li, Zi-Yao; Liu, Hui-Qiang; Wang, Yi-Fei; Huang, Yun-Sheng; European Journal of Medicinal Chemistry; vol. 174; (2019); p. 181 – 197;,
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Adding a certain compound to certain chemical reactions, such as: 140373-17-7, 2-Amino-2-(4-fluorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 140373-17-7, blongs to alcohols-buliding-blocks compound. Formula: C8H10FNO

Step 1 4-(4-Fluorophenyl)oxazolidin-2-one 600 mg of 2-amino-2-(4-fluorophenyl)ethan-1-ol and 80 mg of potassium carbonate were suspended in 914 mg of diethyl carbonate, and the mixture was stirred at 130 C. for 2.5 hours, and further stirred at 100 C. for 2.5 hours while removing the ethanol that was generated. The reaction solution was diluted with ethyl acetate. The solution was washed in turn with water and brine and then dried over magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 610 mg of the objective compound as pale yellow oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,140373-17-7, its application will become more common.

Reference:
Patent; NIPPON SHINYAKU CO., LTD.; US2011/288065; (2011); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 27489-62-9, name is trans-4-Aminocyclohexanol, molecular formula is C6H13NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: trans-4-Aminocyclohexanol

To a solution of di-tert-butyl dicarbonate (4.087 mL, 21.01 mmol) and diisopropylethylamine (2.87 mL, 17.4 mmol) in THF (60 mL) was added (1R,4R)-4-aminocyclohexanol (2.00 g, 17.4 mmol) and was stirred at rt for 4h. The reaction was concentrated to dryness and the residue was dried under reduced pressure to yield the title compound as a white solid (3.49 g, 87.0% yield), which was used without further purification.

With the rapid development of chemical substances, we look forward to future research findings about 27489-62-9.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; CAI, Min; ARORA, Nidhi; BACANI, Genesis M.; BARBAY, Joseph Kent; BEMBENEK, Scott D.; CHEN, Wei; DECKHUT, Charlotte Pooley; EDWARDS, James P.; GHOSH, Brahmananda; KREUTTER, Kevin D.; LI, Gang; TICHENOR, Mark S.; VENABLE, Jennifer D.; WEI, Jianmei; WIENER, John J. M.; WU, Yao; XIAO, Kun; ZHANG, Feihuang; ZHU, Yaoping; (524 pag.)WO2018/103060; (2018); A1;,
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Electric Literature of 7287-81-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7287-81-2, name is 1-(m-Tolyl)ethanol, molecular formula is C9H12O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Take a reaction tube, add 49 mg of sodium azide, 41 mg of 1-(3-methylphenyl)ethanol, and 400 uL of trifluoroacetic acid.200 uL of methanesulfonic acid and 1.0 mL of n-hexane were stirred at 40 C for 6 hours.After the reaction was quenched with 10mL of sodium hydroxide solution was added, extracted 3 times with ethyl acetate, the organic was washed with brine by adding 5mL, the combined organic phases,The nuclear magnetic yield of m-methylaniline was 53%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7287-81-2, 1-(m-Tolyl)ethanol.

Reference:
Patent; Peking University; Jiao Ning; Liu Jianzhong; (27 pag.)CN109134267; (2019); A;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 311-86-4, name is 2-Bromo-3,3,3-trifluoropropan-1-ol, the common compound, a new synthetic route is introduced below. Quality Control of 2-Bromo-3,3,3-trifluoropropan-1-ol

54 g of 2-bromo-3,3,3-trifluoropropanol, 79 g of methanol, 9.7 g of activated RaneyNi catalyst and 19.3 g of potassium carbonate were charged into a 300 mL autoclave, stirred, evacuated and replaced with hydrogen After three times, pressure 5Mpa, heated to 80 ° C, the reaction 3.0h, stop the reaction, cooling, discharge, distillation to 3,3,3 – trifluoropropanol; Yield 95.0percent.

The synthetic route of 311-86-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Xi’an Modern Chemistry Research Institute; Gu, Yujie; Lu, Jian; Ma, Hui; Wang, Zhixuan; Kang, Jianping; Du, Yongmei; Tu, Donghuai; Wan, Hong; Li, Yang; (5 pag.)CN105399607; (2016); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1611-56-9, name is 11-Bromoundecan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Safety of 11-Bromoundecan-1-ol

Oxalyl chloride (2.0 ml_, 24 mmol) was dissolved in dichloromethane (80 ml_) in an oven-dried 250-mL round-bottom flask, equipped with stir bar, in an argon atmosphere. The reaction mixture was cooled in a dry ice/acetone bath, before adding dimethyl sulfoxide (3.4 ml_, 48 mmol) in dichloromethane (10 ml_), dropwise. The reaction mixture was aged 5 mins before adding bromoundecanol (5.0 g, 20 mmol) in dichloromethane (20 ml_), dropwise. The reaction mixture was aged 5 mins before adding triethylamine (13.9 ml_, 100 mmol), dropwise. The reaction mixture was aged 10 mins before the bath was removed, and the reaction mixture allowed to warm slowly to ambient temperature. Dichloromethane (50 ml_) and deionized water (50 ml_) were added and the resulting layers separated. The aqueous layer was extracted with dichloromethane (50 ml_). The combined organic layers were washed with 1.2 M HCI (2 X 50 ml_) and brine (50 ml_). The organic layer was dried over MgS04 and the solvents removed in vacuo. The resulting yellow oil was filtered through a plug of silica, eluting with 10:1 v/v hexanes:ethyl acetate to afford the product as a white, waxy solid (4.57g, 92 %).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1611-56-9, 11-Bromoundecan-1-ol.

Reference:
Patent; TDA RESEARCH, INC.; MARTIN, Rhia, M.; GIN, Douglas, L.; NOBLE, Richard, D.; NGUYEN, Vinh, The; ELLIOTT, Brian, J.; (0 pag.)WO2020/14263; (2020); A1;,
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