Application of 3279-95-6, Adding some certain compound to certain chemical reactions, such as: 3279-95-6, name is 2-(Aminooxy)ethanol,molecular formula is C2H7NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3279-95-6.
EXAMPLE 802-(2-Fluoro-4-iodophenylamino)-5,5-dimethyl-8-oxo-5,6J,8-tetrahydro-4H-thieno[2,3- clazepme-S-carboxylic acid (2-hvdroxyethoxy)amide; Example 2 (1.0 g, 2.6 mmol), EDC (362 mg, 2.9 mmol), etaOBT (300 mg, 2.9 mmol), NMM (427 mg, 5.2 mmol) and 0-(2-hydroxyethyl)hydroxylamine (163 mg, 2.6 mmol) in DMF (10 mL) and DCM (9 mL) were stirred for 48 h. The reaction mixture was poured onto water and extracted with DCM, the unreacted acid removed by filtration and the remaining organic phase washed with IM aqueous HCl then dried over sodium sulphate and concentrated in vacuo. Chromatography (silica; ethyl acetate) yielded the title compound. deltaeta (DMSOd6) 11.22 (IH, br s), 8.82 (IH, br s), 7.93 (IH, t, J4.6 Hz), 7.64 (IH, dd, J 10.7, 2.1 Hz), 7.48 (IH, d, J 8.5 Hz), 7.08 (IH, t, J 8.5 Hz), 4.71 (IH, br s), 3.81-3.74 (2H, m), 3.59-3.50 (2H, m), 2.86 (2H, d, J5.0 Hz), 2.65 (2H, s), 0.97 (6H, s). LCMS (ES+) RT 2.85 minutes, 534 (M+H)+.
According to the analysis of related databases, 3279-95-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; UCB PHARMA S.A.; WO2008/20206; (2008); A2;,
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