As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 150192-39-5, name is (2-Bromo-5-methoxyphenyl)methanol, molecular formula is C8H9BrO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: (2-Bromo-5-methoxyphenyl)methanol
Dissolve (2-bromo-5-methoxy-phenyl) -methanol (5.0 g, 23 mmol) in dry dichloromethane (120 mL) and cool to 0 [C] under nitrogen. Add ethyl vinyl ether (2.5 g, [34 MMOL)] followed by [PYRIDINIUMP-TOLUENESULFONATE (580] mg, 2.3 mmol). Warm to room temperature and stir for 2 hours. Pour reaction into saturated aqueous sodium bicarbonate and extract twice with dichloromethane. Combine organic layers and wash with water and brine. Dry with sodium sulfate, filter and concentrate in vacuo to yield 6.6 g (100%) of title compound as a clear colorless [OIL.’H] NMR [(CDC13)] 8 7.41 (d, J= 8.6 Hz, 1H), 7. 08 (d, [J =] 3.1 Hz, 1H), 6.71 (dd, J= 8.8, 3.1 Hz, 1H), 4. [88] (q, J= 5.3 Hz, 1H), 4.65 (ab, Jab = 13.3 Hz, H), 4.55 (ab, Jab = 13.3 Hz, 1H), 3.8 (s, 3H), 3.71 (m, [1H),] 3.55 (m, [1H),] 1.41 (d, [J=] 5.3 Hz, 3H), 1.23 (t, [J=] 7.0 Hz, 3H).
With the rapid development of chemical substances, we look forward to future research findings about 150192-39-5.
Reference:
Patent; ELI LILLY AND COMPANY; WO2004/9578; (2004); A2;,
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