Reference of 558-42-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 558-42-9, name is 1-Chloro-2-methyl-2-propanol. This compound has unique chemical properties. The synthetic route is as follows.
DIPEA (0.061 mL, 0.348 mmol) and l-chloro-2-methylpropan-2-ol (0.018 mL, 0.174 mmol) were added to (S)-l-(6-methoxy-5-methylpyridin-3-yl)-3-(piperidin-3-ylmethoxy)-4,5,7,8- tetrahydro-lH-oxepino[4,5-c]pyrazole (48 mg, 0.116 mmol) in EtOH (1 mL). The reaction mixture was heated to 90 °C for 1 h in a microwave. l-Chloro-2-methylpropan-2-ol (0.018 mL, 0.174 mmol) was added to the reaction mixture which was heated in a microwave for a further 2 h at 90 °C. 1-Chloro- 2-methylpropan-2-ol (0.018 mL, 0.174 mmol) was added to the reaction mixture which was heated in a microwave for a further 5 h. The reaction mixture was concentrated under a stream of nitrogen and purified using MDAP (Method A) to give the title compound (44.5 mg, 86percent). LCMS (Method C) : Rt = 1.31 min, MH+ = 445. 1H NMR (400 MHz, CDCb) delta ppm 7.92 (d, 2=2 Hz, 1H), 7.46 – 7.40 (m, 1H), 4.17 (dd, J=10, 3 Hz, 1H), 4.06 (dd, J=10, 6 Hz, 1H), 3.98 (s, 3H), 3.85 (t, J=5 Hz, 2H), 3.79 (t, J=5 Hz, 2H), 3.70-3.19 (m, 2H), 2.91 – 2.71 (m, 4H), 2.72-2.44 (m, 5H), 2.22 (s, 3H), 1.97 – 1.76 (m, 3H), 1.41 – 1.20 (m, 7H)
According to the analysis of related databases, 558-42-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; BAXTER, Andrew; BERTRAND, Sophie Marie; CAMPBELL, Matthew; DOWN, Kenneth David; HAFFNER, Curt Dale; HAMBLIN, Julie Nicole; HENLEY, Zoe Alicia; MILLER, William Henry; TALBOT, Eric Philippe Andre; TAYLOR, Jonathan Andrew; (325 pag.)WO2018/192864; (2018); A1;,
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