As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1467-84-1, name is (trans-4-Aminocyclohexyl)methanol, molecular formula is C7H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 1467-84-1
REFERENCE SYNTHETIC EXAMPLE 19 4-{[trans-4-(Hydroxymethyl)cyclohexyl]amino}-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide To a solution of 4-chloro-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide (680 mg, 2.09 mol) obtained in Reference Synthetic Example 7 in N,N-dimethylacetamide (1.1 mL), N,N-diisopropylethylamine (1.1 mL) and (trans-4-aminocyclohexyl)methanol (945 mg, 7.31 mmol) obtained in Reference Synthetic Example 12 were added, and the mixture was stirred at 130C for 3 hours. The reaction mixture was allowed to cool to room temperature, mixed with saturated aqueous ammonium chloride and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane=5/1) (v/v)) to obtain the title compound as a white solid (781 mg, yield: 89%).
With the rapid development of chemical substances, we look forward to future research findings about 1467-84-1.
Reference:
Patent; Nissan Chemical Industries, Ltd.; TAKAHASHI, Keiji; WATANABE, Tsuneo; HAYASHI, Keishi; KURIHARA, Kazunori; NAKAMURA, Takanori; YAMAMOTO, Akio; NISHIMURA, Takuya; KAMIYAMA, Toshihiko; HIDAKA, Yuuki; EP2955181; (2015); A1;,
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