Application of 13330-96-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13330-96-6, name is 4-(Dimethylamino)butan-1-ol, molecular formula is C6H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Tetramethylazodicarboxamide (0.4 mmol) was added to an ice-cooled solution of phenol (24, 0.2 mmol), alcohol (0.3 mmol) and tributylphosphine (0.4 mmol) in anhydrous benzene (1 mL). The reaction mixture was then heated at 90 C for 12 hours. The reaction mixture was concentrated and the residue was purified by column chromatography (SiO2, Methanol: DCM, 2:98) to afford a white amorphous solid (56%). The product was dissolved in MeOH/THF (1:1) and palladium on carbon (10% w/w, 20 mg) was added to the solution under inert atmosphere. The resulting mixture was then stirred under hydrogen atmosphere overnight. The reaction mixture was filtrated through celite and concentrated to get phenol (~100%). Diisopropylazodicarboxylate (0.2 mmol) was added to an ice-cooled solution of phenol (0.1 mmol), N-methyl-4-hydroxy-piperidine (0.15 mmol) and triphenylphosphine (0.2 mmol) in anhydrous THF (1 mL) and resulting solution was then allowed to stir at room temperature for 12 hours. The reaction mixture was concentrated under reduced pressure and the residue was purified by prep-TLC (SiO2, Methanol:DCM:NH4OH, 1:10:0.1) to afford a white amorphous solid (30%).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13330-96-6, 4-(Dimethylamino)butan-1-ol.
Reference:
Article; Garg, Gaurav; Zhao, Huiping; Blagg, Brian S.J.; Bioorganic and Medicinal Chemistry; vol. 25; 2; (2017); p. S1 – S58;,
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