Electric Literature of 1450754-41-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1450754-41-2, name is 2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol, molecular formula is C7H10N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-2-picolinic acid (0.065) with a monocarboxylic acid g, 0.145mmol)Dissolved in 3mL anhydrous tetrahydrofuran solution,Add EDC·HCl (0.04 g, 0.218 mmol),HOBT (0.024g, 0.174mmol)Stir well at 0 C,Then DIPEA (0.094 g, 0.725 mmol) was added dropwise and stirred for 1 h.A linker (0.02 g, 0.145 mmol) containing a photoaffinity group diaziridine and an alkynyl group was added.Stir at room temperature for 24 h, after the reaction is over,The organic solvent was removed by a low pressure, and the mixture was washed with water and saturated aqueous sodium hydrogen carbonate. The organic phase obtained after washing with saturated brine was dried over anhydrous sodium sulfate and evaporated. Separating the crude product by column separation,The title compound was obtained by eluting with petroleum ether / ethyl acetate (V/V = 1/3), weight: 0.12 g, yield 14.7%.A compound represented by the general formula (X) based on the VEGFR-2 inhibitor sorafenib photoaffinity probe was obtained.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1450754-41-2, 2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol.
Reference:
Patent; Xi’an Jiaotong University; Zhang Jie; Lu Wen; Wang Sicen; Pan Xiaoyan; He Langchong; Sun Ying; Wang Jin; Song Jie; (9 pag.)CN109456261; (2019); A;,
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