Related Products of 3279-95-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3279-95-6, name is 2-(Aminooxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows.
General procedure: To a solution of 10 mg (0.012 mmol) of compounds 9a or 9b in anhydrous and deoxygenated THF, 2-(aminooxy)ethanol (1.5 mg, 0.02 mmol) and PTSA (2 mg) were added. The reaction was performed in a glass pressure tube (Ace pressure tube from Aldrich), purged with argon and stirred at room temperature for 6 h. The consumption of starting material 9a-b was monitored by TLC and UVeVis spectroscopy. The solvent was removed under reduced pressure when no starting material was detected. The purification was carried out by flash column chromatography in silica gel using dichloromethane:methanol 99:1 as eluent, and the chlorin derivatives were crystallized from CH2Cl2/hexane. 21,22[N,N-dicarbonyl-N-4-(O-2-hydroxyethyloxime)phenyl]-13,17-bis[2-(methoxycarbonyl)ethyl]-2,7,12,18-tetramethyl-18-vinyl-2,21,22,23-tetrahydrobenzo[b]porphyrin (10a): Yield: 7.5 mg; 8.0 mmol; 70%. 1H NMR (CDCl3, 400 MHz) delta (ppm): -2.47–2.39 (sl, 2H); 2.09 (s, 3H); 3.16 (t, 2H, J=7.9 Hz); 3.21 (t, 2H, J=8.1 Hz); 3.41 (s, 3H); 3.46-3.48 (m, 2H); 3.50 (s, 3H); 3.56 (s, 3H); 3.65 and 3.68 (2s, 3H and 3H); 3.73 (t, 2H, J=4.4 Hz); 3.93-3.97 (m, 1H); 4.09-4.07 (m, 2H); 4.18 (t, 2H, J=7.8 Hz); 4.31 (t, 2H, J=7.5 Hz), 4.68 (d, 1H, J=8.7 Hz); 4.72 (br.s,1H); 6.15 (dd, 1H, J=1.3 Hz and 11.5 Hz, H-8(2a)); 6.35 (dd, H, J=1.3 Hz and 17.9 Hz); 6.77-6.74 (m, 2H); 7.17-7.15 (m, 2H); 7.42 (t, 1H, J=5.3 Hz); 7.76 (s, 1H); 8.19 (dd, 1H, J=17.9 and 11.5 Hz); 9.09 (s, 1H, H-20); 9.33 (s, 1H, H-5); 9.68 (s, 1H); 9.86 (s, 1H). 13C NMR (CDCl3,100 MHz) delta (ppm): 11.4 (1CH3); 11.6 (1CH3); 12.3 (1CH3); 21.5 (1CH2); 21.9 (1CH2); 25.6 (1CH2); 26.4 (1CH3);36.6 (1CH2); 37.0 (1CH2); 38.5 (1CH); 50.1 (1CH); 51.7 (1CH3); 51.8(1CH3); 52.3 (1C); 62.0 (1CH2); 75.1 (1CH2); 90.4 (1CH); 93.2 (1CH); 98.0 (1CH); 99.8 (1CH); 115.5 (1CH); 121.3 (1CH2); 126.2 (2CH); 127.1 (2CH); 129.2 (1C); 129.8 (1CH); 130.9 (1C); 131.5 (1C); 132.57 (1C); 132.64 (1C); 133,8 (1C); 133.9 (1C); 136.3 (1C); 136.5 (1C); 138.3 (1C); 138.4 (1C); 139.7 (1C); 148.1 (1CH); 149,6 (1C); 151.1 (1C); 151.4 (1C); 152.1 (1C); 165.8 (1C); 173.4 (1C); 173.8 (1C); 174.6 (1C); 178.4 (1C). HRMS (ESI-TOF): m/z calculated for [M+] 850.3685; found 850.3684. UV-Vis (CH2Cl2) lambdamax nm (log epsilon) 407 (5.14), 503 (4.00), 540 (4.00), 610 (3.57), 668 (4.50).
According to the analysis of related databases, 3279-95-6, the application of this compound in the production field has become more and more popular.
Reference:
Article; Dos Santos, Fabiane A.B.; Uchoa, Adjaci F.; Baptista, Mauricio S.; Iamamoto, Yassuko; Serra, Osvaldo A.; Brocksom, Timothy J.; De Oliveira, Kleber T.; Dyes and Pigments; vol. 99; 2; (2013); p. 402 – 411;,
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