Reference of 30951-66-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 30951-66-7, name is 2-(3-Bromophenyl)propan-2-ol. A new synthetic method of this compound is introduced below.
4.2 2-[3-(6-Aminopyridin-3-yl)phenyl]propan-2-ol Under a stream of argon, 9.0 g of compound obtained in stage 4.1, 11.05 g of 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylamine, 83.7 ml of a 2M solution of sodium carbonate and 1.70 g of tetrakis(triphenylphosphine)palladium are placed in a round-bottomed flask, and dissolved in 523 ml of N,N-dimethylformamide. The mixture is heated for 1 h 30 at 80 C. After cooling to ambient temperature, 1 l of ethyl acetate is added to the reaction medium, and the mixture is filtered through celite. The organic phase is then separated, washed 3 times with a saturated solution of sodium chloride, dried over magnesium sulphate and concentrated under reduced pressure. The residue is purified by silica gel chromatography, elution being carried out with a dichloromethane/methanol mixture. The solid obtained is triturated from diisopropyl ether, recovered by filtration, and then oven-dried under reduced pressure. 2.35 g of compound are obtained. 1H NMR (DMSO-d6, delta in ppm): 1.45 (s, 6H); 5.0 (s, 1H); 6.0 (s, 2H); 6.55 (d, 1H); from 7.3 to 7.4 (m, 3H); 7.65 (s, 1H); 7.7 (d, 1H); 8.25 (s, 1H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,30951-66-7, its application will become more common.
Reference:
Patent; SANOFI-AVENTIS; US2011/65745; (2011); A1;,
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