Adding a certain compound to certain chemical reactions, such as: 140373-17-7, 2-Amino-2-(4-fluorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 140373-17-7, blongs to alcohols-buliding-blocks compound. Formula: C8H10FNO
Step 1 4-(4-Fluorophenyl)oxazolidin-2-one 600 mg of 2-amino-2-(4-fluorophenyl)ethan-1-ol and 80 mg of potassium carbonate were suspended in 914 mg of diethyl carbonate, and the mixture was stirred at 130 C. for 2.5 hours, and further stirred at 100 C. for 2.5 hours while removing the ethanol that was generated. The reaction solution was diluted with ethyl acetate. The solution was washed in turn with water and brine and then dried over magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 610 mg of the objective compound as pale yellow oil.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,140373-17-7, its application will become more common.
Reference:
Patent; NIPPON SHINYAKU CO., LTD.; US2011/288065; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts