Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1611-56-9, name is 11-Bromoundecan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Safety of 11-Bromoundecan-1-ol
Oxalyl chloride (2.0 ml_, 24 mmol) was dissolved in dichloromethane (80 ml_) in an oven-dried 250-mL round-bottom flask, equipped with stir bar, in an argon atmosphere. The reaction mixture was cooled in a dry ice/acetone bath, before adding dimethyl sulfoxide (3.4 ml_, 48 mmol) in dichloromethane (10 ml_), dropwise. The reaction mixture was aged 5 mins before adding bromoundecanol (5.0 g, 20 mmol) in dichloromethane (20 ml_), dropwise. The reaction mixture was aged 5 mins before adding triethylamine (13.9 ml_, 100 mmol), dropwise. The reaction mixture was aged 10 mins before the bath was removed, and the reaction mixture allowed to warm slowly to ambient temperature. Dichloromethane (50 ml_) and deionized water (50 ml_) were added and the resulting layers separated. The aqueous layer was extracted with dichloromethane (50 ml_). The combined organic layers were washed with 1.2 M HCI (2 X 50 ml_) and brine (50 ml_). The organic layer was dried over MgS04 and the solvents removed in vacuo. The resulting yellow oil was filtered through a plug of silica, eluting with 10:1 v/v hexanes:ethyl acetate to afford the product as a white, waxy solid (4.57g, 92 %).
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Reference:
Patent; TDA RESEARCH, INC.; MARTIN, Rhia, M.; GIN, Douglas, L.; NOBLE, Richard, D.; NGUYEN, Vinh, The; ELLIOTT, Brian, J.; (0 pag.)WO2020/14263; (2020); A1;,
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