Extracurricular laboratory: Synthetic route of trans-4-Aminocyclohexanol

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 27489-62-9, trans-4-Aminocyclohexanol.

Application of 27489-62-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 27489-62-9, name is trans-4-Aminocyclohexanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a flask was added 29 B008 (0.4g, 1.07mmol), 102 DMSO (10mL), 103 K2CO3 (0.3g, 2.14mmol), 104 3-chloro-4-fluoroaniline (0.31g, 2.14mmol). The mixture was heated and stirred at 90C for 8h, cooled to rt, poured into ice-water (50mL). The solid was collected by filtration and recrystallized from methanol 4 times to afford a white 105 solid (0.23g, yield 45%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 27489-62-9, trans-4-Aminocyclohexanol.

Reference:
Article; Feng, Yue; Xie, Xiao-Yang; Yang, Yi-Qiu; Sun, Yu-Tong; Ma, Wen-Hui; Zhou, Peng-Jun; Li, Zi-Yao; Liu, Hui-Qiang; Wang, Yi-Fei; Huang, Yun-Sheng; European Journal of Medicinal Chemistry; vol. 174; (2019); p. 181 – 197;,
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