Related Products of 96-35-5 ,Some common heterocyclic compound, 96-35-5, molecular formula is C3H6O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of methyl glycolate (2.5 g, 27.7 mmol) in pyridine (10 mL) was added tert-butyldiphenylsilyl chloride (8.4 g, 30.5 mmol). A catalytic amount of DMAP was added at 0 C, and the reaction was stirred overnight at room temperature. H2O was then added and the resulting mixture was extracted with CH2Cl2 (3 × 10 mL), the organic phase was dried with MgSO4, concentrated under vacuum and purified by flash chromatography (5:95 EtOAc/hexane) to give 8 as a colourless oil (8.86 g, 97% yield). 1H NMR (400 MHz, CDCl3): delta 7.69-7.68 (m, 4H), 7.43-7.37 (m, 6H), 4.25 (s, 2H), 3.68 (s, 3H), 1.09 (s, 9H). 13C NMR (100 MHz, CDCl3): delta 171.7, 135.6, 132.8, 129.9, 127.8, 62.1, 26.7, 19.3. FT-IR (film): 1760 (CO). M/z 271.0 (M+-tBu), 251.1 (M+-Ph). Elemental Anal. Calcd: C, 69.47; H, 7.36. Obtained: C, 69.50; H, 7.08.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,96-35-5, its application will become more common.
Reference:
Article; Ascenso, Osvaldo S.; Marques, Joao C.; Santos, Ana Rita; Xavier, Karina B.; Rita Ventura; Maycock, Christopher D.; Bioorganic and Medicinal Chemistry; vol. 19; 3; (2011); p. 1236 – 1241;,
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