Reference of 16308-92-2 , The common heterocyclic compound, 16308-92-2, name is (2,4-Dimethylphenyl)methanol, molecular formula is C9H12O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example 7 Synthesis of Dmb protected 6-mercaptohexanoic acid 7 Compound 7 was synthesized according to the following scheme: To a solution of 6-mercaptohexanoic acid (7.10 g, 47.90 mmol) in trifluoroacetic acid (20 mL), 2,4-dimethylbenzyl alcohol (13.5 g, 95.80 mmol) was added. The mixture was stirred at rt for 60 min and then the trifluoroacetic acid was removed in vacuo. The residue was dissolved in a mixture of 95.8 mL LiOH (3 M) and THF (81 mL) and stirred at rt for 60 min. The solvent was removed in vacuo and the aqueous residue was extracted 3x with EtOAc (200 mL). The combined organic phases were dried over MgSO4, and the solvent was removed in vacuo.7 was purified by RP-HPLC. Yield: 2.27 g (8.52 mmol, 18 %) MS: m/z 267.01 = [M+H]+ , (calculated monoisotopic mass = 266.13).
The synthetic route of 16308-92-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASCENDIS PHARMA GROWTH DISORDERS A/S; SPROGØE, Kennett; RAU, Harald; CLEEMANN, Felix; HERSEL, Ulrich; RASMUSSEN, Caroline Elisabeth; (244 pag.)WO2017/118703; (2017); A1;,
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