In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 627-18-9, name is 3-Bromopropan-1-ol, the common compound, a new synthetic route is introduced below. Formula: C3H7BrO
To a stirring solution of concentrated sulfuric acid (30 mmol) was slowly added concentrated nitric acid (30 mmol) dropwise at 0 C under nitrogen, and stirred for 10 min followed by the addition of 3-bromopropanol 3 (3.5 g, 25 mmol) in anhydrous dichloromethane (5 mL) dropwise while keeping the temperature below 5 C. After 3 h, the reaction was quenched with water (10 mL), followed by addition of dichloromethane (40 mL). The organic phase was separated, washed with water (15 mL), dried (MgSC ) and concentrated to give bromopropyl nitrate 4, which was used in the next step without further purification.
The synthetic route of 627-18-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; VIRGINIA COMMONWEALTH UNIVERSITY; SAFO, Martin, K.; DANSO-DANQUAH, Richmond; GHATGE, Mohini; VENITZ, Jurgen; MANGINO, Martin; WARD, Kevin, R.; WO2015/100235; (2015); A1;,
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