The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 17100-58-2, name is (4-Bromo-2-methylphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks
Step B: 4-Bromo-1-chloromethyl-2-methyl-benzene(4-Bromo-2-methyl-phenyl)-methanol (40.0 g, 199 mmol) was added to thionyl chloride (106.6 g, 0.896 mole, 65.3 mL) .The mixture was heated to reflux, for 1.5 hours. After cooling to room temperature the mixture was concentrated under reduced pressure. The residue was dissolved in EtOAc (300 mL) and added carefully to saturated aqueous NaHC03 (500 mL). The EtOAc layer was separated, and the aqueous layer was extracted with EtOAc (250 mL). The combined organic layers were dried (Na2S04), filtered and concentrated in vacuo yielding the title compound (34.19 g, 157 mmol, 79 %) as a slightly colored oil that solidified to a white solid upon standing.1 H NMR (CDCI3, 300 MHz) delta ppm 2.38 (s, 3H); 4.57 (s, 2H); 7.12 (d, 1 H); 7.28 (s, 1 H); 7.55 (d, 1 H)
With the rapid development of chemical substances, we look forward to future research findings about 17100-58-2.
Reference:
Patent; PFIZER INC.; BROWN, Matthew Frank; MARFAT, Anthony; MELNICK, Michael Joseph; REILLY, Usa; WO2011/45703; (2011); A2;,
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