Electric Literature of 5299-60-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5299-60-5, name is Ethyl 6-hydroxyhexanoate. A new synthetic method of this compound is introduced below.
General procedure: According to a modified literature procedure,[2] a flame-dried Schlenk flask is charged withpoly(4-vinylpyridine) (2.1 equiv) in CH2Cl2. At 0 C, Tf2O (1.1 equiv) is added dropwisefollowed by the addition of the corresponding primary alcohol in CH2Cl2. The reaction mixtureis then allowed to warm to room temperature. After completion of reaction (TLC monitoring),the reaction mixture is filtered under gravity, and the residue is washed with CH2Cl2.Evaporation of the solvents at room temperature (due to decomposition of the triflates athigher temperatures) affords the crude title compounds. Purification by vacuum filtration oversilica gel using a sintered funnel (grade 4) with the indicated eluent affords the analyticallypure alkyltriflates.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5299-60-5, its application will become more common.
Reference:
Article; Scharfbier, Jonas; Oestreich, Martin; Synlett; vol. 27; 8; (2016); p. 1274 – 1276;,
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