Related Products of 623-04-1 , The common heterocyclic compound, 623-04-1, name is (4-Aminophenyl)methanol, molecular formula is C7H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 4-aminobenzyl alcohol (2.0g, 16.24mmol) in dry DMF (20mL) were added tert-butyldimethylsilyl chloride (3.67g, 24.35mmol) and imidazole (2.21g, 32.46mmol), the resulting mixture was further stirred for 5hat room temperature. The reaction mixture was then diluted with saturated brine solution and extracted with CH2Cl2. The organic layer was separated and washed with brine solution for several times, then dried over anhydrous Na2SO4, evaporated under vacuum, the obtained brown residue was purified by silica gel chromatography (petroleum ether-ethyl acetate), a brown oil was obtained (3.15g, 82%). 1H NMR (CDCl3, 400MHz) delta7.12 (d, 2H, J=8.4Hz), 6.67 (d, 2H, J=8.0Hz), 4.62 (s, 2H), 3.80 (brs, 2H), 0.91 (s, 9H), 0.08 (s, 6H).
The synthetic route of 623-04-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Fei, Qiang; Zhou, Li; Wang, Feiyi; Shi, Ben; Li, Chunbao; Wang, Rui; Zhao, Chunchang; Dyes and Pigments; vol. 136; (2017); p. 846 – 851;,
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