Synthetic Route of 637031-88-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.637031-88-0, name is 3,3-Difluorocyclobutanol, molecular formula is C4H6F2O, molecular weight is 108.09, as common compound, the synthetic route is as follows.
To a 10-mL Schlenk tube were added Example 8f (240 mg, 0.8 mmol), Example lj (130 mg, 1.2 mmol), K2C03 (221 mg, 1.6 mmol) and DMF (4 mL). The tube was sealed and heated at 80C for 16 hours. The reaction was cooled to room temperature. Water (10 mL) was added, the mixture was extracted by EtOAc (10 mL*3). The combined organic phase was washed with brine, dried over Na2SO4, filtrated and concentrated under reduced pressure to give the crude product which was further purified by silica gel chromatography to give the pure product Example 8g (92 mg, yield 30%) as a white solid. ?H NMR (400 IVIHz, Chloroform-d) 7.36 (d, J 8.6 Hz, 1H), 6.86 (d, J 8.6 Hz, 1H), 4.77 (d, J= 9.3 Hz, 1H), 4.39-4.33 (m, 2H),4.28-4.23 (m, 2H), 3.13 (ddt, J 18.9, 12.3, 6.5 Hz, 2H), 2.94-2.81 (m, 2H).
Statistics shows that 637031-88-0 is playing an increasingly important role. we look forward to future research findings about 3,3-Difluorocyclobutanol.
Reference:
Patent; FRONTHERA U.S. PHARMACEUTICALS LLC; JIN, Bohan; DONG, Qing; HUNG, Gene; (151 pag.)WO2018/31680; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts