Synthetic Route of 5020-41-7, Adding some certain compound to certain chemical reactions, such as: 5020-41-7, name is 2-(3-Methoxyphenyl)ethanol,molecular formula is C9H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5020-41-7.
Preparation B 2-(3-Methoxyphenyl)ethylbromide 114.1 g (750 mmol) of 2-(3-methoxyphenyl)ethanol was dissolved in 500 mL of benzene and cooled to 0 C. 35.5 mL (375 mmol) of PBr3 was slowly added to the stirring reaction and the reactin then heated to reflux under a nitrogen atmosphere for three hours. The reaction was quenched by the addition of water and the organic layer separated. The aqueous layer was washed twice with benzene and all the benzene extracts were combined. The benzene extract was washed twice with brine, dried with Na2 SO4, and evaporated to an oil. The oil was distilled and the fraction at 115-124 C. a 4 mm Hg was taken. This yielded 131.7 g of the title compound as a clear oil. PMR: Consistent with the proposed structure. MS: m/e=214, 216 (M) FD EA: Calc: C, 50.26; H, 5.16 Fd: C, 50.22; H, 5.02 C9 H11 BrO
According to the analysis of related databases, 5020-41-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Eli Lilly and Company; US5952350; (1999); A;,
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