The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 15258-73-8, name is (2,6-Dichlorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Safety of (2,6-Dichlorophenyl)methanol
[Example 10] Synthesis of sodium 2,6-dichlorobenzyloxymethyl trifluoroborate To the mixture of sodium hydride (61 %, 180 mg, 4.5 mmol) and tetrahydrofuran (6 ml), 2,6-dichlorobenzyl alcohol (740 mg, 4.2 mmol) was added at 0C (an outer temperature), and the obtained reaction mixture was stirred at room temperature for 1 hour. To the reaction mixture, 2-(bromomethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (92%, 500 mg, 2.1 mmol) synthesised in Production Example 2 and dissolved in tetrahydrofuran (4 ml) was added at 0C (an outer temperature), and the obtained mixture was stirred at 30C (an outer temperature) overnight. After cooling the reaction mixture to 0C (an outer temperature), sodium hydrogen fluoride (590 mg, 4.5 mmol) was added to the reaction mixture at the same temperature, followed by the dropwise addition of water (8 ml) at the same temperature. After stirring the reaction mixture for 30 minutes at room temperature, the solvents were evaporated under reduced pressure. Acetone (40 ml) was added to the obtained residue, followed by filtration. The solvents were evaporated under reduced pressure from the filtrate, and then the obtained residue was washed with diethyl ether, thereby obtaining the entitled compound (460 mg, 78%). 1H-NMR Spectrum (DMSO-d6) delta(ppm): 2.61(2H, q, J=5.4Hz), 4.46(2H, s), 7.30-7.35(1H, m), 7.44(2H, d, J=8.0Hz)
With the rapid development of chemical substances, we look forward to future research findings about 15258-73-8.
Reference:
Patent; Eisai R&D Management Co., Ltd.; EP2062901; (2009); A1;,
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