Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 50595-15-8, name is tert-Butyl 2-hydroxyacetate. This compound has unique chemical properties. The synthetic route is as follows. Safety of tert-Butyl 2-hydroxyacetate
To a solution of Compound 37A (200 mg, 0.28 mmol) and DIAD (60 mg, 0.30 mmol) in THF (0.5 mL) was added a solution of triphenylphospine (78 mg, 0.30 mmol) and t-butyl-2-hydroxy acetate in THF (0.5 mL) dropwise. The resulting mixture was stirred for 18 hours and concentrated in vacuo. The residue was purified by silica gel chromatography (0 – 100 % EtOAc/Hexanes) to afford Compound 38A (170 mg, 75 %). S)-2-(( -(2-(4-(3-chloro-2-methyl-N-(l-(3-(3-methylpyridin-4-yl)phenyl)ethyl) phenylsulfonamido)butanamido)ethyl)sulfamoyl)amino)acetic acid (Compound 38) Compound 38A (170 mg, 0.21 mmol) was dissolved in 4 N HC1 (dioxane, 6 mL) and stirred for 2 hours. The mixture was partioned between EtOAc and water. The organic layers were concentrated in vacuo and the residue was purified by reverse phase chromatography (5-100% water/ AcN 0.25 % formic acid) to afford Compound 38 as the formate salt (41 mg, 29 %). LCMS (method A): m/z 666.4/668.4 (M+H)+. lH NMR (CDC13) delta 12.66 (bs, IH), 8.44 (bs, IH), 8.39 (d, IH), 7.85 (d, IH), 7.70 (t, IH), 7.65 (d, IH), 7.37 (q, 2H), 7.29-7.23 (m, 2H), 7.12 (t, IH), 7.07 (d, IH), 7.01 (s, IH), 6.82 (bs, IH), 4.93 (q, IH), 3.48 (d, 2H), 3.22-2.93 (m, 4H), 2.76 (m, 2H), 2.11 (s, 3H), 1.91-1.79 (m, 2H), 1.62-1.51 (m, IH), 1.49 (d, 3H), 1.38-1.24 (m, IH).
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 50595-15-8, tert-Butyl 2-hydroxyacetate.
Reference:
Patent; VENENUM BIODESIGN LLC; HUANG, Chia-Yu; SHI, Dongchuan; KULTGEN, Steven G.; MCGUINNESS, Brian F; LETOURNEAU, Jeffrey J.; COLE, Andrew G.; BEASLEY, James R.; (358 pag.)WO2018/5801; (2018); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts