In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6850-65-3, name is 4-Aminocyclohexan-1-ol(isomers mixture), the common compound, a new synthetic route is introduced below. category: alcohols-buliding-blocks
To a microwave reactor vessel is added 4-(2,3- dimethoxyphenyl) -2-fluorobenzonit?le (0.23 g, 0.89 mmol) , 4- hydroxylcyclohexylamine (0.21g, 1.79 mmol), N, N- diisopropylethylamme (0.23 g, 1.79 mmol), and DMSO (2 mL) . The mixture is microwaved at 150 0C for 1500 sec with high absorbance. The mixture is extracted with ethyl acetate (100 mL) , washed with brine (2 X 50 mL) , and dried over MgSO4. The crude product is purified by a silica gel column with chloroform/methanol (95:5) as the eluent, affording 0.17 g of the desired 4- (2, 3-Dimethoxyphenyl) -2- (4- hydroxylcyclohexylamino) benzonitrile (54%) as a white solid. LCMS m/z = 353 [M+H] .
The synthetic route of 6850-65-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SERENEX, INC.; WO2008/24963; (2008); A1;,
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