Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 37729-18-3, name is 2-([1,1′-Biphenyl]-4-yl)ethanol. A new synthetic method of this compound is introduced below., SDS of cas: 37729-18-3
Under nitrogen atmosphere, to a stirred solution of 2-(4-phenylphenyl)-ethanol (0.30 g,1.41 mmol) in dry CH2C12 (15 mL), DMAP (0.014 g, 0.11 mmol) and 2-DPC (0.37 g, 1.70mmol) were added. The reaction mixture was stirred at r.t. for 16h, then diluted with CH2C12 (15mL) and sequentially washed with sat. NH4C1 solution (15 mL) and sat. NaHCO3 solution (315 mL). The organic layer was dried over Na2SO4, filtered and concentrated to dryness giving an oily residue (0.46 g), as a mixture (1:1.7 ratio) of 2-(4-phenylphenyl)-ethyl-2-pyridyl carbonate and 2-(4-phenylphenyl)-ethyl-2-oxopyridine- 1 -carboxylate. The mixture of isomers was not separated and used in the next step without any further purification. R = 2.63 mm. MS (ESI)m/z: 244 [M-H], 266 [M-Na]. MS (ESI) m/z: 242 EM-Hr.
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Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA; PIOMELLI, Daniele; BANDIERA, Tiziano; BERTOZZI, Fabio; NUZZI, Andrea; FIASELLA, Annalisa; PONZANO, Stefano; PAGLIUCA, Chiara; REGGIANI, Angelo Mario; WO2014/144836; (2014); A2;,
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