Adding a certain compound to certain chemical reactions, such as: 109-83-1, 2-(Methylamino)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 109-83-1, blongs to alcohols-buliding-blocks compound. Safety of 2-(Methylamino)ethanol
Example 1 N-(2-hydroxy-ethyl)-4-methoxy-2.6,N-trimethyl-benzenesulphonamide (C) [0152] 3,5-dimethylanisol (A) were dissolved in 50.0 L dichloromethane. After cooling to -35 C. a solution of 17.46 kg (149.85 mol) chlorosulphonic acid in 15.0 L dichloromethane was metered in and the mixture was stirred for about another 30 minutes at -35 C.±5 C. After the reaction was complete 40.0 L of water were metered in at -35 C. to 5 C. and then the organic phase was separated off. The organic phase was diluted with 10.0 L dichloromethane, before a solution of 1.23 kg (14.69 mol) of sodium hydrogen carbonate in 29.0 L water was added. After separation of the organic phase and dilution with 10 L of dichloromethane, a solution consisting of 11.58 kg (154.20 mol) of N-methylaminoethanol (B) in 20.0 L dichloromethane was slowly metered in at 10±5 C. After the reaction was complete, a mixture of 42.0 L water and 4.10 kg (42.59 mol) conc. hydrochloric acid was added, starting at 10 C. The organic phase was separated off, diluted with 10.0 L of dichloromethane and the product ( C) was totally freed from the solvent in vacuo. [0154] Yield: 14.34 kg (71% of theory)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,109-83-1, its application will become more common.
Reference:
Patent; Boehringer Ingelheim International GmbH; Pachur, Thorsten; Pfrengle, Waldemar; Birk, Manfred; Schnaubelt, Juergen; Werthmann, Ulrike; US2013/289049; (2013); A1;,
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