Electric Literature of 558-42-9, Adding some certain compound to certain chemical reactions, such as: 558-42-9, name is 1-Chloro-2-methyl-2-propanol,molecular formula is C4H9ClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 558-42-9.
To a stirred solution of 54 (3.4 g, 12.0 mmol) in dry DMF (20 mL), Cs2CO3 (7.7 g, 24.0 mmol) and 1-chloro-2-methylpropan-2-ol 55 (1.6 g, 14.0 mmol) were added and heated at 90°C for 16 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was quenched with water and extracted with EtOAc. The combined organic layer were washed with brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford 56. Yield: 1.7 g, 40percent. ?H NIVIR (400 MHz, DMSO-d6) 1.06- 1.11 (m, 4H), 1.21 (s, 6H), 2.13 -2.22 (m, 2H), 2.55 -2.60 (m, 1H), 3.01-3.07 (m, 1H), 3.76 (s, 2H), 4.84-4.94 (m, 2H), 5.00 – 5.19 (m, 1H), 5.53-5.60 (m, 1H), 6.91-6.98 (m, 1H), 7.10- 7.18 (m, 1H), 7.24 -7.31 (m, 1H), 8.26 (s, 1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 558-42-9, 1-Chloro-2-methyl-2-propanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CV6 THERAPEUTICS (NI) LIMITED; SPYVEE, Mark; LEWIS, Michael; (300 pag.)WO2018/98204; (2018); A1;,
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