Synthetic Route of 349-75-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
4,6-dimethyl-5-nitro-2-hydroxypyridine (350 mg, 2.08 mmol)Dissolved in 15 mL of dry tetrahydrofuran3-trifluoromethylbenzyl alcohol (0.44 g, 2.50 mmol) was added in the presence of nitrogen,Triphenylphosphine(1.09 g, 4.16 mmol), cooled to 0 C, and azodicarbonyl diisopropyl ester (0.84 mg, 4.16 mmol) was slowly added dropwise. After the drop is finished, the roomStir for three hours. Spin-dried tetrahydrofuran, crude using petroleum ether / ethyl acetate = 30: 1 column to obtain compound 6A, whiteColor solid (589 mg, 86% yield).
According to the analysis of related databases, 349-75-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Jiangsu Xiansheng Pharmaceutical Co., Ltd.; Chen Huanming; Liang Bo; Zhao Zhongqiang; Cao Wenjie; Li Amin; Chen Dexin; Gao Chunhua; Zhang Peng; Xu Wanmei; Chen Xuelian; Zhang Lili; (29 pag.)CN103508943; (2017); B;,
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