Application of 23377-40-4, Adding some certain compound to certain chemical reactions, such as: 23377-40-4, name is 3-(Hexadecyloxy)propan-1-ol,molecular formula is C19H40O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 23377-40-4.
General procedure: 4.1. General method A Bis isopropyl phosphonoethoxyethylchloride (1) (2.58 g,10.0 mmol) or bis isopropyl phosphonomethyltosylate (7) (3.50 g,10.0 mmol) in anhydrous acetonitrile (130 ml) was treated withbromotrimethylsilane (13 ml) overnight at room temperature.The mixture was then evaporated and codistilled with acetonitrile (3×25 mL), water (2×25 ml), ethanol (25 mL) and toluene (3 x 25 mL). The syrupy residue was dissolved in dichloromethane (50 ml) then DMF (0.1 ml) and oxalyl chloride (6.0 ml, 68.8 mmol) were added. The solution was gently refluxed (2 h), evaporated to dryness, and redissolved in dichloromethane (20 ml). The solution was cooled down to 0 C and treated slowly with pyridine (1.6 ml).The mixture was added to a cooled ( 30 C) solution of hexadecyloxypropanol (6.01 g, 20 mmol) in dichloromethane (100 ml) and triethylamine (8.7 ml). The mixture was allowed to reach 0C and kept at this temperature for3 h.The reactionmixturewas evaporated,codistilled with toluene (3 50 ml) and the residue was chromatographed on a silica gel column (400 g) in EtOAc/hexane (1:2/1:1). 4.1.1. Bis(hexadecyloxypropyl)phosphonoethoxyethylchloride (2) Yield 6.50 g of syrup (88%). The crude product was used without further purification procedures. ESI-MS, m/z: 753.6 (53) [M th H]th, 775.6 (100) [M th Na]th, 791.5 (22) [M th K]th, 812.7 (28); ESI-HRMS calcd for C42H87O6ClP 753.59233, found: 753.59185 [M th H]th.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 23377-40-4, 3-(Hexadecyloxy)propan-1-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Tichy, Tomas; Dracinsky, Martin; Krecmerova, Marcela; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; European Journal of Medicinal Chemistry; vol. 55; (2012); p. 307 – 314,8;; ; Article; Tichy, Tomas; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; Dracinsky, Martin; Krecmerova, Marcela; European Journal of Medicinal Chemistry; vol. 55; (2012); p. 307 – 314;,
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