Reference of 7218-43-1 ,Some common heterocyclic compound, 7218-43-1, molecular formula is C7H12O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
120mg NaH (60%) was added to a solution of 144mg 1-propargyl diethylene glycol in 5mL THF,Stir at room temperature for 15 minutes, then add 152 mg of bromoacetic acid and heat to reflux for 6 hours.After the reaction was completed, 10 mL of saturated ammonium chloride solution was added to quench the reaction, and the organic phase was separated.The aqueous phase was extracted three times with dichloromethane and incorporated into the organic phase,It was washed successively with saturated aqueous ammonium chloride solution and saturated brine, and then dried over anhydrous sodium sulfate,The sodium sulfate was removed by filtration and concentrated to obtain the crude product.The crude product was isolated by column chromatography (200-300 mesh silica gel, eluent dichloromethane: methanol = 50: 1) to obtain pure intermediate 26.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7218-43-1, 2-[2-(2-Propynyloxy)ethoxy]ethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ShanghaiTech University; Tao Houchao; Zhao Fei; (85 pag.)CN110894209; (2020); A;,
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