In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 71176-54-0, name is (5-Amino-1,3-phenylene)dimethanol, the common compound, a new synthetic route is introduced below. Quality Control of (5-Amino-1,3-phenylene)dimethanol
Compound 3d (5.6 g, 18.52 mmol) was dissolved in anhydrous dichloromethane (1 18 mL) and anhydrous methanol (58.8 mL). (5-amino-1 ,3- phenylene)dimethanol (2.70 g, 17.64 mmol) and EEDQ (8.72 g, 35.3 mmol) were then added, and the reaction was stirred at room temperature overnight. The solvent was stripped and ethyl acetate was added. The resulting slurry was filtered, washed with ethyl acetate, and dried under vacuum/N2 to give compound 3e (2.79 g, 36% yield). 1 H NMR (400 MHz, DMSO-d6): delta 9.82 (s, 1 H), 8.05, (d, 1 H, J = 9.2 Hz), 8.01 (d, 1 H, J = 7.2 Hz), 7.46 (s, 2H), 6.95 (3, 1 H), 5.21 -5.12 (m, 2H), 4.47-4.42 (m, 4H), 4.40-4.33 (m, 1 H), 4.33-4.24 (m, 1 H), 3.58 (s, 3H), 2.33-2.26 (m, 2H), 2.16-2.09 (m, 2H), 1 .54-1 .46 (m, 4H), 1 .30 (d, 3H, J = 7.2 Hz), 1 .22 (d, 3H, J = 4.4 Hz).
The synthetic route of 71176-54-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MILLENNIUM PHARMACEUTICALS, INC.; IMMUNOGEN, INC.; VEIBY, Ole Peter; CHARI, Ravi, V. J.; LAMBERT, John M.; LAI, Katharine C.; HERBST, Robert W.; HILDERBRAND, Scott A.; (128 pag.)WO2017/136693; (2017); A1;,
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