Adding a certain compound to certain chemical reactions, such as: 84832-00-8, (5-Amino-2-fluorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 84832-00-8, blongs to alcohols-buliding-blocks compound. Quality Control of (5-Amino-2-fluorophenyl)methanol
Example 205 : 1 -(2-Fluoro-5 -morpholinobenzyl)-N-( 1 -methyl- 1 H-pyrazol-4-yl)- 1 H- pyrazo lo [3 ,4-d]pyrimidin-6-amineStep (i) To a solution of 5-Amino-2-fluoro benzyl alcohol (500mg, 3.5mmol) in toluene (12mL) was added DIEA (2eq) and 2-bromoethylether (1.5eq) and the reaction heated to 90C for 18h. The solvent was removed in vacuo and the residue partitioned between EtOAc and H20. The organic phase was dried (Na2S04), filtered and concentrated in vacuo. The resultant residue was purified by column chromatography (petroleum ether: EtOAc) to give 2(2-fluoro-5- morpholinophenyl)methanol (550mg, 74%) as a yellow oil.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,84832-00-8, its application will become more common.
Reference:
Patent; CELLZOME LIMITED; RAMSDEN, Nigel; HARRISON, Richard John; OXENFORD, Sally; BELL, Kathryn; PITON, Nelly; DAGOSTIN, Claudio; BOUSSARD, Cyrille; RATCLIFFE, Andrew; WO2011/48082; (2011); A1;,
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