Reference of 647-42-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, molecular formula is C8H5F13O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctane-1-ol (20 g,55 mmol) and triphenylphosphine (15.7 g, 60 mmol) were dissolved in 110 ml of anhydrous acetonitrile and deoxygenated with argon. The mixture was heated at 60 C and bromine (9.6 g,60 mmol) was added dropwise. The mixture was stirred for 5 h at this temperature. After cooling down to room temperature, the reaction mixture was extracted with diethyl ether and the ether layers were washed with brine. After drying with Na2SO4, the ether was evaporated and the crude product was dissolved in 100 ml of dichloromethane. This solution was stirred with 50 g of silica gel for 2 h and then filtered and evaporated. The crude product was distilled at reduced pressure.
According to the analysis of related databases, 647-42-7, the application of this compound in the production field has become more and more popular.
Reference:
Article; Luka?, Milo?; Garajova, Maria; Mrva, Martin; Devinsky, Ferdinand; Ondriska, Franti?ek; Kubincova, Janka; Journal of Fluorine Chemistry; vol. 164; (2014); p. 10 – 17;,
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