Adding a certain compound to certain chemical reactions, such as: 23377-40-4, 3-(Hexadecyloxy)propan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 23377-40-4, blongs to alcohols-buliding-blocks compound. SDS of cas: 23377-40-4
Oxalylchloride (2.04 mL, 3 eq., 23.8 mmol) was added to a solution of dimethyl allylphosphonate (1 .19 g, 1 eq., 7.9 mmol) in dichloromethane (35 mL). This mixture was gently refluxed during 3 days at 45C. After evaporation of all volatiles, the crude compound was diluted in 35 mL of dichloromethane. Hexadecyloxypropyl alcohol (2.5 g, 1 .05 eq., 8.3mmol) and freshly distilled triethylamine (1 .6 mL, 1 .5 eq., 20 mmol) were then added subsequently and the resulting solution was refluxed during 3 days at 45C. The volatiles were removed under reduced pressure, and the residue was purified by flash column chromatography (eluting PE/EtOAc 9:1 – 6:4 – 0:1 ) to afford 209 as a white amorphous solid. (2.52 g, 76%) 1H NMR (400 MHz, CDCI3) d 5.75 (m, 1 H, CH=CH2), 5.23 (m, 2H, CH2-CH=CH2), 4.13 (dt, J = 6.5, 1 .7 Hz, 2H, He), 3.73 (d, J = 10.9 Hz, 3H, 0-CH3), 3.48 (t, J = 6.2 Hz, 2H, Ha), 3.38 (t, J = 6.7 Hz, 2H, CH2-0), 2.62 (ddt, J = 22.0, 7.4, 1 .1 Hz, 2H, CH2-P), 1 .91 (p, J = 6.3Hz, 2H, CH2-b), 1 .54 (p, J = 6.9 Hz, 2H, CH2-CH2-0), 1 .32-1 .22 (m, 26H, CH2), 0.87 (t, J= 6.8 Hz, 3H, CH3). 31P NMR (162 MHz, CDC ) d 28.3. CAS: 1258789-65- 9
At the same time, in my other blogs, there are other synthetic methods of this type of compound,23377-40-4, 3-(Hexadecyloxy)propan-1-ol, and friends who are interested can also refer to it.
Reference:
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE D’ORLEANS; NEOVIRTECH; AGROFOGLIO, Luigi; ROY, Vincent; DE SCHUTTER, Coralie; BESSIERES, Maxime; GALLARDO, Franck; (93 pag.)WO2019/206907; (2019); A1;,
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