In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol, the common compound, a new synthetic route is introduced below. category: alcohols-buliding-blocks
To a solution of A5 (219g, 1.05mol) in 1,2-dichloroethane (3500mL) was added Boc-D-Pro (141g, 0.65mol) followed by EDCI (163g, 0.85mol) and DMAP (21.57g, 0.18mol) at 0 C. The resulting mixture was stirred at r.t. overnight and then water (3500mL) was added and separated, the water phase was extracted withDCM(1500mLx3), dried over MgS04, concentrated and purified by column chromatography to (PE:EA=30:1) to give Bl (55.96g, yield: 51.1%)
The synthetic route of 756520-66-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; XCOVERY HOLDING COMPANY, LLC; LIANG, Congxin; WO2012/48258; (2012); A2;,
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