Related Products of 37585-25-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 37585-25-4, name is (2-Amino-5-chlorophenyl)methanol, molecular formula is C7H8ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a stirred solution of 2-amino-5-chlorophenylmethanol (11.1g, 70.4mmol) in tetrahydrofuran (50mL) was added imidazole (5.27g, 77.5mmol), followed by careful addition of terf-butyldimethylchlorosilane (10.62g, 70.4mmol). The reaction mixture was stirred for 24 hours. Imidazole (528mg, 7.75mmol) and tert-butyldimethylchlorosilane (1.06g, 7.03mmol) were then added. After 1 hour the solid was filtered off and washed with diethyl ether (2 x 20ml_) and the filtrate was washed with water (10mL), brine (10ml_), dried over magnesium sulfate and concentrated in vacuo to give the product as a brown oil, 18.83g (98%).1H NMR (400 MHz, CDCI3): 5 0.07 (6H, s), 0.90 (9H, s), 4.63 (2H, s), 6.60 (1H, d), 7.01 (1H, d), 7.05 (1H, m); LRMS: m/z APCI+272[MH+].
According to the analysis of related databases, 37585-25-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2006/21882; (2006); A1;,
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