New downstream synthetic route of Sodium isethionate

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1562-00-1, Sodium isethionate.

Related Products of 1562-00-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1562-00-1, name is Sodium isethionate. This compound has unique chemical properties. The synthetic route is as follows.

N-[(3S,4S)-6-Acetyl-3-hydroxy-2,2-di methyl-3,4-di hydro-2H- 1 -benzopyran-4-yl]-3-chloro-4- fluorobenzamide (3.92g, 10.Ommol) and pyridine (2.5mL) were dissolved in DCM (125mL) and triphosgene (980mg, 3.33mmol) was added. The reaction mixture was stirred for 2h. Sodium isethionate (1.48g, 10.Ommol) was added and the reaction mixture was stirred overnight. The rection mixture was diluted with DCM (50mL) and EtOAc (100mL) and washed with brine, dried (Mg504) and concentrated in vacuo. The residue was dissolved in EtOAc (50mL), filtered and passed through a plug of silica. The residue was triturated from diisopropyl ether then hexane to give the title compound (133mg, 2.3%) as a cream solid.LCMS (ESj: 544.0 [MH].

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1562-00-1, Sodium isethionate.

Reference:
Patent; PROXIMAGEN LIMITED; SAVORY, Edward; HILL, Daniel; KOCIAN, Oldrich; WO2014/140510; (2014); A1;,
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