Synthetic Route of 4084-38-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4084-38-2, name is 2,3,5,6-Tetrafluorobenzyl alcohol, molecular formula is C7H4F4O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
2,3,5,6-tetrafluorobenzyl alcohol (30 mg, 0.17 mmol) and(1 R) -trans-3 – [(E) -2-methoxy-1-ethenyl]-2,2-dimethylcyclopropanecarboxylic acid (43 mg, 0.25 mmol)1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (48 mg, 0.25 mmol) and 4-dimethylaminopyridine (3 mg) were added to a chloroform solution (2 mL).After stirring at room temperature for 20 hours, water was poured into the reaction solution,This was extracted with ethyl acetate. After drying the organic layer with magnesium sulfate,Concentrate under reduced pressure, The residue was subjected to silica gel column chromatography,Represented by the following formula (X)2,3,5,6-tetrafluorobenzyl (1 R) -trans-3-[(E) -2-methoxy-1-ethenyl]-2,2-dimethylcyclopropanecarboxylate (hereinafter referred to as “This compound is referred to as the compound 9 of the present invention. ) 18 mg.
According to the analysis of related databases, 4084-38-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; DAINIHON JOCHUGIKU COMPANY LIMITED; MATSUO, NORITADA; KOUTANI, YASUYUKI; NAKAYAMA, KOJI; (27 pag.)JP2018/43961; (2018); A;,
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