Adding a certain compound to certain chemical reactions, such as: 149965-40-2, (5-Bromo-2-chlorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks
General procedure: . To a solution of the benzyl alcohol in DCM (400mL) was added Dess-Martinperiodinane (216g, 510mmol) at 0oC,the mixture was allowed to warm to room temperature and stirred for 2h. Thereaction mixture was cooled to 0oC. Saturated NaHCO3 solution was added slowly to quench the reaction and stirred until it no gasgenerated. The reaction mixture washed with brine. The organic layer was driedover Na2SO4, filtered and evaporated in vacuo. The cruderesidue was purified by column chromatography on silica gel (hexane) to yield the title compound.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,149965-40-2, (5-Bromo-2-chlorophenyl)methanol, and friends who are interested can also refer to it.
Reference:
Article; Ding, Yuyang; Mao, Liufeng; Xu, Dengfeng; Xie, Hui; Yang, Ling; Xu, Hongjiang; Geng, Wenjun; Gao, Yong; Xia, Chunguang; Zhang, Xiquan; Meng, Qingyi; Wu, Donghai; Zhao, Junling; Hu, Wenhui; Bioorganic and Medicinal Chemistry Letters; vol. 25; 14; (2015); p. 2744 – 2748;,
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