Synthetic Route of 111-46-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.111-46-6, name is 2,2′-Oxybis(ethan-1-ol), molecular formula is C4H10O3, molecular weight is 106.1204, as common compound, the synthetic route is as follows.
A mixture of 2- (2-methoxyethoxy) ethanol(2A) (21.2 g, 0.2 mol) andCesium carbonate (8.55 g, 0.05 mol) was dissolved in N, N-dimethylformamide (50 mL), Benzyl bromide (27.7 g, 0.085 mol) was added and stirred at room temperature for 3 daysThe The reaction solution was added with water (300 mL) and extracted with ethyl acetate (100 mL x 2)The combined organic phases were washed with saturated brine, dried over anhydrous sodium sulfate,The filtrate was concentrated under reduced pressure and the residue was purified by silica gel column chromatography(Petroleum ether / ethyl acetate (v / v) = 1: 0 to 5: 1) to give the title product2- (2-benzyloxyethoxy) ethanol (2B) as a pale yellow oil(4.0 g, yield 40%).
The chemical industry reduces the impact on the environment during synthesis 111-46-6, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd.; Wei, Yonggang; Qiu, Guanpeng; Lu, Yonghua; Zhu, Guozhi; (40 pag.)TW2017/8238; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts