As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10488-69-4, name is Ethyl 4-chloro-3-hydroxybutanoate, molecular formula is C6H11ClO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of Ethyl 4-chloro-3-hydroxybutanoate
To 1 L of a 3-necked round bottom flask equipped with a thermometer, a pH meter and a stirrer, 64.8 g of glycinamide hydrochloride, 98.5 g of sodium bicarbonate and 500 mL of ethyl alcohol were successively added and stirred at a room temperature for 1 hour. To the solution, 97.7 g of ethyl- (S)-4-chloro-3-hydroxybutyric was dropwisely added. The reaction solution was further stirred at 80°C for 20 hours. Work-up procedures were performed in the same manner as mentioned in the Example 7. Recrystallization with methyl alcohol and acetone gave 52.5 g of the targeted (S)-4-hydroxy-2-oxo- I -pyrrolidine acetamide.
With the rapid development of chemical substances, we look forward to future research findings about 10488-69-4.
Reference:
Patent; AHN-GOOK PHARMACEUTICAL CO., LTD.; RSTECH CORPORATION; WO2005/115978; (2005); A1;,
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