In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22436-06-2, name is (S)-2-Methyl-3-phenylpropan-1-ol, the common compound, a new synthetic route is introduced below. Formula: C10H14O
General procedure: To a CH2Cl2 solution (2 mL) of the (Sax)-chloride 1a (429 mg,1.0 mmol) was added a solution of 2-methyl-1-hexanol (2a)(119 mg, 1.0 mmol) in CH2Cl2 (1 mL) and Et3N (0.14 mL,1.0 mmol) at room temperature under an Ar atmosphere. Theresulting solution was stirred at reflux in CH2Cl2 for 6.5 h.The reaction mixture was poured into water and extracted withCH2Cl2. The organic layer was dried over MgSO4, filtered, concentrated,and purified by column chromatography on silicagel (CH2Cl2:hexane = 1:5) to give the corresponding ester 3a(429 mg, 84%, 54 : 46) as a white solid.
The synthetic route of 22436-06-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Murai, Toshiaki; Itoh, Hikaru; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 191; 2; (2016); p. 163 – 173;,
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