The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 55414-72-7, name is (2-Amino-5-methoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 55414-72-7
A mixture of compound 6 (0.081 g, 0.35 mmol) and thionyl chloride (1.12 mL, 15.4 mmol) was stirred at reflux for 5 h. The excess thionyl chloride was removed and the residue was cooled to 0 C. Aqueous saturated sodium bicarbonate solution (10 mL) and a solution of compound 4 (0.046 g, 0.30 mmol) in methanol (2 mL) were added slowly with rapid stirring. The mixture was stirred at room temperature overnight and the resultant pink-orange solid was collected and washed with aqueous HCl (1 M, 5 mL), water (5 mL), diethyl ether (5 mL) and hexane (5 mL). The solid was dried to obtain the title compound as a sticky orange powder (0.063 g, 58%); 1H NMR (300 MHz, CDCl3): delta 3.81 (s, 3H), 3.82 (s, 3H), 4.71 (s, 2H), 6.82-6.93 (m, 3H), 7.17 (d, J = 3.1 Hz, 1H), 7.49 (d, J = 8.8 Hz, 1H), 7.91 (d, J = 8.8 Hz, 1H), 8.57 (br s, 1H); this material was carried forward to the next step without further purification.
With the rapid development of chemical substances, we look forward to future research findings about 55414-72-7.
Reference:
Article; Lizarme, Yuvixza; Wangsahardja, Jonatan; Marcolin, Gabriella M.; Morris, Jonathan C.; Jones, Nicole M.; Hunter, Luke; Bioorganic and Medicinal Chemistry; vol. 24; 7; (2016); p. 1480 – 1487;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts