Synthetic Route of 25055-82-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 25055-82-7, name is 2-(3-Methyl-3H-diazirin-3-yl)ethanol. A new synthetic method of this compound is introduced below.
A solution of 2-(3-methyl-3H-diazirin-3-yl)ethan-i-ol (100 mg, 1.0 mmol) and triethylamine (160 mu, 1.15 mmol) in dichloromethane (5 mL) was cooled in an ice bath. To the cooled solution was added methanesulfonyl chloride (93 mu, 1.2 mmol). The reaction mixture was stirred for 1.5 hours in the ice bath, then saturated ammonium chloride was added and the organic layer was separated. The aqueous layer was extracted once with dichloromethane. The organic layers were combined, dried over sodium sulfate, filtered and then concentrated in vacuo to afford the title compound (178 mg, quantitative yield) which was used without further purification. (1292) NMR (CDC13): delta = 4.13 (t, 2 Eta), 3.05 (s, 3 Eta), 1.79 (t, 2 Eta), 1.09 (s, 3 Eta).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,25055-82-7, its application will become more common.
Reference:
Patent; INFLAZOME LIMITED; COOPER, Matthew; MILLER, David; MACLEOD, Angus; VAN WILTENBURG, Jimmy; THOM, Stephen; ST-GALLAY, Stephen; SHANNON, Jonathan; (352 pag.)WO2019/8025; (2019); A1;,
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