Reference of 52273-77-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52273-77-5, name is 2-(3-Aminophenyl)ethanol, molecular formula is C8H11NO, molecular weight is 137.179, as common compound, the synthetic route is as follows.
A solution of 2-(3-aminophenyl)ethanol (1.8 mmol), 2-chloro-5-(4-difluoromethoxy- phenyl)-pyrimidine 30 (1.8 mmol) and p-TSA (1.8 mmol) in dioxane (10 mL) is heated at 100 0C for 12 h then cooled to rt. The reaction mixture is slowly added to water (100 mL) with stirring. The resulting precipitate is collected by filtration, washed with water and air dried. The crude precipitate of 2-(3-(5-(4-(difluoromethoxy)phenyl)pyrimidin-2-ylamino)phenyl)ethanol
The chemical industry reduces the impact on the environment during synthesis 52273-77-5, I believe this compound will play a more active role in future production and life.
Reference:
Patent; IRM LLC; WO2009/26276; (2009); A1;,
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