The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111-90-0, name is Diethylene Glycol Monoethyl Ether. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 111-90-0
General procedure: To a solution of 4 (50 mg, 0.08 mmol, 1 equiv) in DMF (2 mL), N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) (39.6 mg, 0.16 mmol, 2 equiv) was added and the mixture was stirred for 10 minutes at room temperature. N,N-Diisopropylethylamine (DIEA) (20.7 mg, 0.16 mmol, 2 equiv) was added to the reaction at room temperature. In a separate flask, alkyl amine or alcohol (0.12 mmol, 1.5 equiv) was dissolved in DMF (2 mL) and added to the reaction mixture. The reaction was then heated to 60 C and continued for 12 hours. The reaction progress was monitored by TLC until completion. The productwas extracted in DCM (10 mL) and washed with H2O (3 x 10 mL) and brine (10 mL). The organic layer was dried with Na2SO4, filtered and concentrated in vacuo prior to purification by silica gel column chromatography.
With the rapid development of chemical substances, we look forward to future research findings about 111-90-0.
Reference:
Article; Patel, Pradeepkumar; Hanawa, Emi; Yadav, Reeta; Samuni, Uri; Marzabadi, Cecilia; Sabatino, David; Bioorganic and Medicinal Chemistry Letters; vol. 23; 18; (2013); p. 5086 – 5090;,
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