Application of 702-82-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 702-82-9, name is 3-Aminoadamantan-1-ol, molecular formula is C10H17NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a mixture of 1-aminoadamantane-3-ol (2.00 g, 12.0 mmol) and potassium carbonate (2.48 g,18.0 mmol, 1.5 equiv) in 60 mL of tetrahydrofuran is added benzyl chloroformate (1.88 mL, 13.2mmol, 1,1 equiv) in dropwise fashion over a 10-minute period. The mixture is then stirred at room temperature for 2 h and then partitioned between ethyl acetate and water. The product is then extracted into the ethyl acetate and the aqueous layer is washed twice with ethyl acetate (100 ml). The combined organic layers are then washed successively with 100 mL of aqueous 2 N sodium hydroxide, water and brine, dried over sodium sulfate, filtered and concentrated to provide 1-benzylcarbamoyladamantane-3-ol as a white solid (3.32g, 92% yield). This compound was used without further purification.1H NMR (500 MHz, CDCl3): delta 7.36-7.28 (m, 5H), 5.02 (s, 2H), 4.78 (br s, 1H), 2.25 (s, 2H), 2.00(br s, 1H), 1.92 (s, 2H), 1.84 (s, 4H), 1.67 (s, 4H), 1.52 (q, J = 12.7 Hz, 2H) ppm.13C NMR (125 MHz, CDCl3): delta 154.2, 136.5, 128.4, 128.0, 126.9, 69.1, 66.0, 65.1, 53.2, 49.2,43.9, 40.4, 34.7, 30.5 ppm. Spectroscopic data matches with previously reported data.8
According to the analysis of related databases, 702-82-9, the application of this compound in the production field has become more and more popular.
Reference:
Article; Gonzalez-Esguevillas, Maria; Miro, Javier; Jeffrey, Jenna L.; MacMillan, David W.C.; Tetrahedron; vol. 75; 32; (2019); p. 4222 – 4227;,
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